CAJ | 학술논문

　　目的探讨高维持量氯吡格雷对不稳定型心绞痛患者高敏C反应蛋白（HsCRP）、P-选择素（P-selectin）的影响。方法选择87例不稳定型心绞痛患者，随机分为三组，所有患者分别于治疗前、治疗一月后采用ELISA法测定三组患者的HsCRP及P-selectin水平。结果三组患者治疗后，Hs-CRP、P-selectin水平均较治疗前下降（P＜0.05），且与A组比较，B组（P＜0.05）、C组（P＜0.01）下降幅度明显，差异有统计学意义。结论氯吡格雷可以有效抑制血管内动脉粥样硬化斑块的炎症反应及血小板活化，高维持量氯吡格雷治疗UAP安全、有效。
　　목적탐토고유지량록필격뢰대불은정형심교통환자고민C반응단백（HsCRP）、P-선택소（P-selectin）적영향。방법선택87례불은정형심교통환자，수궤분위삼조，소유환자분별우치료전、치료일월후채용ELISA법측정삼조환자적HsCRP급P-selectin수평。결과삼조환자치료후，Hs-CRP、P-selectin수평균교치료전하강（P＜0.05），차여A조비교，B조（P＜0.05）、C조（P＜0.01）하강폭도명현，차이유통계학의의。결론록필격뢰가이유효억제혈관내동맥죽양경화반괴적염증반응급혈소판활화，고유지량록필격뢰치료UAP안전、유효。
Objective To explore the effect of High maintenance dose clopidogrel on serum Hs-CRP and P-selectin in patients with unstable angina pectoris. Methods A total of 87 diagnosed unstable angina pectoris patients were enrolled and all subjects were divided into three groups. The level of HsCRP and P-selectin of all subjects were analyzed by double-antibody sandwith ELISA. The statistical data were analyzed by SPSS 13.0 software. Results After treatment,the level of Hs-CRP、P-selectin was decreased(P<0.05),and comparison with A group,the B group(P<0.05)and C group(P<0.01) Decreased obviously. Conclusion Clopidogrel can effectively inhibit inflammation of vascular atherosclerotic plaque and platelet activation,High maintenance dose of clopidogrel is safety and effective to the patients with unstable angina pectoris.