CAJ | 학술논문

　　目的探讨子宫内膜癌中P-21蛋白和环氧化酶-2（Cyclooxygenase-2，COX-2）的表达和意义。方法采用免疫组织化学中的SP法对对照组中20例正常的子宫内膜组织患者、非典型增生组中的7例子宫内膜出现非典型增生组织患者以及子宫内膜癌组中的55例子宫内膜癌组织患者中P-21蛋白及COX-2的表达情况进行检测。结果与非典型增生组和子宫内膜癌组相比，对照组中患者P-21蛋白的阳性表达率显著较高（P＜0.05），而对照组中Cox-2的阳性表达率显著较非典型增生组和子宫内膜癌组低（P＜0.05）；在手术-病理分期和分化程度，以及淋巴结出现转移等宫内膜癌组织的相关方面，P-21蛋白的阳性率具有明显差异（P＜0.05）；Cox-2阳性率在子宫内膜癌组织的手术-病理分期、分化程度、肌层浸润方面差异有统计学意义（P＜0.05），子宫内膜癌组织P-21蛋白阳性表达率与Cox-2阳性呈负相关（r=-0.498，P=0.000）。结论 P-21蛋白和Cox-2异常表达可能在子宫内膜癌的发生、发展中起重要作用。
　　목적탐토자궁내막암중P-21단백화배양화매-2（Cyclooxygenase-2，COX-2）적표체화의의。방법채용면역조직화학중적SP법대대조조중20례정상적자궁내막조직환자、비전형증생조중적7례자궁내막출현비전형증생조직환자이급자궁내막암조중적55례자궁내막암조직환자중P-21단백급COX-2적표체정황진행검측。결과여비전형증생조화자궁내막암조상비，대조조중환자P-21단백적양성표체솔현저교고（P＜0.05），이대조조중Cox-2적양성표체솔현저교비전형증생조화자궁내막암조저（P＜0.05）；재수술-병리분기화분화정도，이급림파결출현전이등궁내막암조직적상관방면，P-21단백적양성솔구유명현차이（P＜0.05）；Cox-2양성솔재자궁내막암조직적수술-병리분기、분화정도、기층침윤방면차이유통계학의의（P＜0.05），자궁내막암조직P-21단백양성표체솔여Cox-2양성정부상관（r=-0.498，P=0.000）。결론 P-21단백화Cox-2이상표체가능재자궁내막암적발생、발전중기중요작용。
Objective To explore the expression and significance of p-21 and Cyclooxygenase-2 protein in endometrial cancer. Methods Immunohistoche mical SP method was used to detect the expressions of p-21 and Cox-2 protein in 20 cases of normal endometrium (control group ), 9 cases of endometrial atypical hyperplasia (atypical hyperplasia group) and 57 cases of endometrial carcinoma (endometrial cancer group) Results The positive rate of p-21 protein was obviously higher in control group than that in the other group(P<0.05). The positive rate of Cox-2 protein in control group was obviously lower than that in the other groups(P<0.05).The positive rate of p-21 protein was significantly different in operation stage ,pathology stage, differentiation degree and lymph metastasis(P<0.05).The positive rate of Cox-2 protein was significantly different in operation stage, pathology stage, differentiation degree and Myometrial invasion(P<0.05)In endometrial carcinoma group, the positive rate of p-21 protein was negatively correlated with the high proliferation rate of Cox-2 (r=-0.498, P=0.000) Conclusion The abnormal expressions of p-21 and Cox-2 protein may play an important role in carcinogenesis and development of endometrial cancer.