CAJ | 학술논문

目的：观察高同型半胱氨酸（Hcy）血症患者炎性反应、血管内皮功能、脉搏波速度的表达。方法选取2012年6月至2013年3月在该院体检中心体检的人群，无高血压、冠心病、糖尿病、脑梗死、肝肾功能不全等病史，依据Hcy水平分为 A、B、C、D 4组，A 组（Hcy＜10μmol/L ）、B组（10μmol/L≤ Hcy＜15μmol/L ）、C组（15μmol/L≤ Hcy＜20μmol/L）、D组（Hcy≥20μmol/L），对入组人群行超敏C反应蛋白（hs-CRP）、血流介导的血管舒张反应（FMD）、硝酸甘油介导的血管舒张反应（NMD）、踝臂脉搏波速度（ba-PWV）检测。结果高 Hcy各组hs-CRP、ba-PWV均高于 Hcy正常组，FMD、NMD低于Hcy正常组，且C、D组与 Hcy正常组比较差异有统计学意义（P＜0．05），D组与B组比较差异有统计学意义（P＜0．05）。对Hcy与ba-PWV进行相关分析，显示二者呈正相关（r＝0．467，P＜0．05），Hcy与hs-CRP差异无统计学意义（P＞0．05）。结论高 Hcy组患者炎性反应、动脉僵硬度较明显，血管内皮功能较差，且这种变化随着H cy水平的升高而更加明显。
목적：관찰고동형반광안산（Hcy）혈증환자염성반응、혈관내피공능、맥박파속도적표체。방법선취2012년6월지2013년3월재해원체검중심체검적인군，무고혈압、관심병、당뇨병、뇌경사、간신공능불전등병사，의거Hcy수평분위 A、B、C、D 4조，A 조（Hcy＜10μmol/L ）、B조（10μmol/L≤ Hcy＜15μmol/L ）、C조（15μmol/L≤ Hcy＜20μmol/L）、D조（Hcy≥20μmol/L），대입조인군행초민C반응단백（hs-CRP）、혈류개도적혈관서장반응（FMD）、초산감유개도적혈관서장반응（NMD）、과비맥박파속도（ba-PWV）검측。결과고 Hcy각조hs-CRP、ba-PWV균고우 Hcy정상조，FMD、NMD저우Hcy정상조，차C、D조여 Hcy정상조비교차이유통계학의의（P＜0．05），D조여B조비교차이유통계학의의（P＜0．05）。대Hcy여ba-PWV진행상관분석，현시이자정정상관（r＝0．467，P＜0．05），Hcy여hs-CRP차이무통계학의의（P＞0．05）。결론고 Hcy조환자염성반응、동맥강경도교명현，혈관내피공능교차，차저충변화수착H cy수평적승고이경가명현。
Objective To observe the inflammatory reaction ,Vascular endothelial function and brachial ankle pulse wave velocity (ba-PWV ) in patients with hyperhomocystinemia .Methods 120 patients from our hospital's medical examination center from 2012 .6 to 2013 .3 without hypertension ,coronary heart disease ,diabetes ,cerebral in-farction ,liver and kidney dysfunction history were chosen .On the basis of homocysteine level ,all the patients were di-vided into group A (Hcy<10 μmol/L) ,group B (10 μmol/L≤ Hcy<15 μmol/L) ,group C (15 μmol/L≤ Hcy<20μmol/L) ,and group D(Hcy≥20 μmol/L) .The hs-CRP ,flow-mediated dilatation (FMD) ,nitroglycerin-mediated dil-atation (NMD) ,and ba-PWV were measured .Results To compare with group A ,there were higher levels of hs-CRP and ba-PWV and lower levels of FMD and NMD in group B ,group C and group D ,there were statistically significant between group C ,D and group A (P<0 .05) ,and there was significant difference between group D and group B (P<0 .05) .Hcy had the positive relationship with ba-PWV (r=0 .467 ,P<0 .05) ,and there was no significant correlation between Hcy and hs-CRP(P>0 .05) .Conclusion Patients with hyperhomocystinemia have serious inflammatory re-action ,arterial stiffness and worse vascular endothelial function than the patients with normal homocysteine ,and the change was obvious with elevated homocysteine levels .