CAJ | 학술논문

目的：探讨胃肠道间质瘤（ GIST ）的临床特点、治疗方法，以提高诊断和治疗效果。方法：回顾分析我院2007年1月～2012年10月17例胃肠道间质瘤患者的临床诊断、治疗、病理及随访。结果：GIST临床表现缺少特异性。17例GIST中，9例（52．9％）发生于胃，6例（35．3％）发生于小肠（其中1例伴肝脏转移），1例（5．9％）发生于直肠，1例（5．9％）发生于左半结肠系膜根部。 CT检查呈现不规则软组织肿块，大部分边界完整。 GIST免疫组织化学表达CD117阳性者16例（94．1％），CD34阳性者15例（88．2％）。2例胃间质瘤患者于术后1年死于远处转移，其余患者尚未发现明显远处转移及复发征象。结论：对于疑似GIST患者，可采用胃镜、超声胃镜、B超、CT等多种手段以明确诊断。对于确诊患者，应根据肿瘤的位置、大小等采用适合手术治疗，以降低其复发率和转移率，提高患者生存期。
목적：탐토위장도간질류（ GIST ）적림상특점、치료방법，이제고진단화치료효과。방법：회고분석아원2007년1월～2012년10월17례위장도간질류환자적림상진단、치료、병리급수방。결과：GIST림상표현결소특이성。17례GIST중，9례（52．9％）발생우위，6례（35．3％）발생우소장（기중1례반간장전이），1례（5．9％）발생우직장，1례（5．9％）발생우좌반결장계막근부。 CT검사정현불규칙연조직종괴，대부분변계완정。 GIST면역조직화학표체CD117양성자16례（94．1％），CD34양성자15례（88．2％）。2례위간질류환자우술후1년사우원처전이，기여환자상미발현명현원처전이급복발정상。결론：대우의사GIST환자，가채용위경、초성위경、B초、CT등다충수단이명학진단。대우학진환자，응근거종류적위치、대소등채용괄합수술치료，이강저기복발솔화전이솔，제고환자생존기。
Objective:To investigate clinical characteristics , treatment methods of gastrointestinal stro-mal tumors ( GIST) to improve the diagnosis and treatment .Methods:The clinical date and follow -up of 17 patients with GIST from January 2007 to 2012 October were analyzed retrospectively .Results:The clinical mani-festations of GSIT were nonspecific.Locations of the tumor included stomach(n=9),small intestine(n=6,in-cluding 1 case with liver metastasis ) , rectal ( n =1 ) and the root of left mesocolon ( n=1 ) .CT examination showed irregular soft tissue mass , and most of them had complete boundary .The immunohistochemical expres-sion of CD117-positive in 16 patients (94.1%), CD34-positive in 15 cases (88.2%).2 cases of gastric GIST patients died of distant metastasis 1 year after surgery, and the remaining patients had not yet found clear signs of distant metastasis and recurrence .Conclusions:For patients with suspected GIST , many methods can be used to confirm the diagnosis , such as endoscopic ultrasound , B ultrasound, CT etc.For diagnosed patients should be given appropriate surgery based on tumor location and size to reduce the recurrence and metastasis , and improve patient survival .