河北北方学院学报:自然科学版
河北北方學院學報:自然科學版
하북북방학원학보:자연과학판
Journa of Hebei North University:Natural Science Edition
2012年
2期
79-81
,共3页
心脉隆注射液%动脉粥样硬化%内皮细胞%大鼠
心脈隆註射液%動脈粥樣硬化%內皮細胞%大鼠
심맥륭주사액%동맥죽양경화%내피세포%대서
Xinmailong injecta%atherosclerosis%vascular endothelial cells%rat
目的探讨心脉隆注射液对动脉粥样硬化(AS)大鼠血管内皮细胞的保护作用.方法采用高脂饲料加维生素D3喂养8周的方法建立动脉粥样硬化大鼠的模型.将大鼠随机分为正常组、模型组、辛伐他汀组、心脉隆治疗组四组,高脂饲料喂养8周后取血测一氧化氮(NO)、内皮素(ET)、前列环素(PGI2)和血栓素(TXA2)的含量.结果心脉隆注射液给药8周后能明显的升高AS大鼠血清NO和血浆PGI2水平(P〈0.05),显著降低血浆ET的含量(P〈0.05).结论心脉隆注射液能保护AS大鼠血管内皮细胞,减轻动脉粥样硬化的进程,对动脉粥样硬化有治疗作用.
目的探討心脈隆註射液對動脈粥樣硬化(AS)大鼠血管內皮細胞的保護作用.方法採用高脂飼料加維生素D3餵養8週的方法建立動脈粥樣硬化大鼠的模型.將大鼠隨機分為正常組、模型組、辛伐他汀組、心脈隆治療組四組,高脂飼料餵養8週後取血測一氧化氮(NO)、內皮素(ET)、前列環素(PGI2)和血栓素(TXA2)的含量.結果心脈隆註射液給藥8週後能明顯的升高AS大鼠血清NO和血漿PGI2水平(P〈0.05),顯著降低血漿ET的含量(P〈0.05).結論心脈隆註射液能保護AS大鼠血管內皮細胞,減輕動脈粥樣硬化的進程,對動脈粥樣硬化有治療作用.
목적탐토심맥륭주사액대동맥죽양경화(AS)대서혈관내피세포적보호작용.방법채용고지사료가유생소D3위양8주적방법건립동맥죽양경화대서적모형.장대서수궤분위정상조、모형조、신벌타정조、심맥륭치료조사조,고지사료위양8주후취혈측일양화담(NO)、내피소(ET)、전렬배소(PGI2)화혈전소(TXA2)적함량.결과심맥륭주사액급약8주후능명현적승고AS대서혈청NO화혈장PGI2수평(P〈0.05),현저강저혈장ET적함량(P〈0.05).결론심맥륭주사액능보호AS대서혈관내피세포,감경동맥죽양경화적진정,대동맥죽양경화유치료작용.
Objective To study the protective effect of Xinmailong(XML) injecta on vascular endothelial cells of the atherosclerosis Rats.Methods AS model of rat was made by feeding high grease food and Vitamin D3,and randomly divided into 4 groups including normal group,model group,simvastatin group and XML injecta group.The contents of NO,ET,PGI2,TXA2 were tested after the rat model of Atherosclerosis was established by feeding high lipid diet for 8 weeks.Results Compared with that of normal group the levels of NO,PGI2 in the XML injecta group increased significantly and the levels of ET decreased notably(P〈0.05).Conclusion XML injecta had the effects of protecting vascular endothelial cells of the atherosclerosis rats and could inhibit the formation and development of atherosclerosis.