国际麻醉学与复苏杂志
國際痳醉學與複囌雜誌
국제마취학여복소잡지
INTERNATIONAL JOURNAL OF ANESTHESIOLOGY AND RESUSCITATION
2014年
4期
377-380
,共4页
白细胞介素-15%穿膜递呈理论%树突状细胞%炎症因子%机制
白細胞介素-15%穿膜遞呈理論%樹突狀細胞%炎癥因子%機製
백세포개소-15%천막체정이론%수돌상세포%염증인자%궤제
Interleukin-15%Theory of trans-presentation%Dendritic cells%Inflammatory factor%Mechamism
背景 白细胞介素(interleukin,IL)-15是4-α螺旋束家族细胞因子的一个成员.近年来对IL-15穿膜递呈理论(theory of trans-presentation of,TTP)及其在炎症反应中的作用进行了很多研究,不断取得进展. 目的 总结TTP以及炎症反应中IL-15发挥功能的机制. 内容 IL-15有广泛的生物学作用.穿膜递呈是把IL-15输送到效应细胞的一种直接而可控的方式,是介导IL-15反应的主要机制.IL-15在炎症反应中通过多种途径发挥促炎症作用.但是在某些情况下,其可能是一种炎症抑制因子. 趋向 研究在何种炎症反应类型、病变阶段以及所在器官,IL-15分别发挥促炎和抗炎作用.
揹景 白細胞介素(interleukin,IL)-15是4-α螺鏇束傢族細胞因子的一箇成員.近年來對IL-15穿膜遞呈理論(theory of trans-presentation of,TTP)及其在炎癥反應中的作用進行瞭很多研究,不斷取得進展. 目的 總結TTP以及炎癥反應中IL-15髮揮功能的機製. 內容 IL-15有廣汎的生物學作用.穿膜遞呈是把IL-15輸送到效應細胞的一種直接而可控的方式,是介導IL-15反應的主要機製.IL-15在炎癥反應中通過多種途徑髮揮促炎癥作用.但是在某些情況下,其可能是一種炎癥抑製因子. 趨嚮 研究在何種炎癥反應類型、病變階段以及所在器官,IL-15分彆髮揮促炎和抗炎作用.
배경 백세포개소(interleukin,IL)-15시4-α라선속가족세포인자적일개성원.근년래대IL-15천막체정이론(theory of trans-presentation of,TTP)급기재염증반응중적작용진행료흔다연구,불단취득진전. 목적 총결TTP이급염증반응중IL-15발휘공능적궤제. 내용 IL-15유엄범적생물학작용.천막체정시파IL-15수송도효응세포적일충직접이가공적방식,시개도IL-15반응적주요궤제.IL-15재염증반응중통과다충도경발휘촉염증작용.단시재모사정황하,기가능시일충염증억제인자. 추향 연구재하충염증반응류형、병변계단이급소재기관,IL-15분별발휘촉염화항염작용.
Background Interleukin(IL)-15,which is one of important T lymphocytes growth factors,is one member of the cytokines family with 4-αhelix in their molecules.Recently,theory of trans-presentation (TTP) of IL-15 and its roles in inflammatory responses have been widely studied.Objective To review the theory of trans-presentation of IL-15 and its mechanism of IL-15 in inflammatory responses.Content IL-15 plays signifficant roles in cytokines responses,lymphocytes,neutrophils and monocytes /macrophages.The cytokine can fight against various pathogens and neoplasms,and can function as an antiapoptotic molecule.It was reported that trans-presentation model,the dominating mechanism inducing IL-15 responses,is one direct and controllable pattern in which way IL-15 is presented to effector cells.At first,IL-15 in cells combines to IL-15R; then the IL-15-IL-15R complex transpresents through membrane to external surface,and fixs on it.Finally,IL-15 functions in the way of paracrine.Dendritic cells may be the main transpresenting cells in this process.IL-15 promotes inflammatory responses by multiple mechanisms,one of which is IL-15-dendritic cells-GSH mode.Trend The type and phage of inflammatory responses,and the role of IL-15 need further research.
