中国保健营养（中旬刊）
中國保健營養（中旬刊）
중국보건영양（중순간）
China Hwalth Care & nutrition
2014年
5期
3230-3231
,共2页
2型糖尿病%黄连素%脂代谢紊乱%动脉硬化
2型糖尿病%黃連素%脂代謝紊亂%動脈硬化
2형당뇨병%황련소%지대사문란%동맥경화
ype 2 diabetes mel itus%berberine%lipid metabolism%Arteriosclerosis
目的：通过观察黄连素对2型糖尿病大鼠血脂和主动脉硬化的影响，评价其对2型糖尿病脂代谢紊乱的治疗作用。方法：70只成年雄性SD大鼠，随机分为正常对照组和实验组。实验组大鼠给予高糖高脂饮食喂养8周后，腹腔注射链脲佐菌素造2型糖尿病大鼠模型。1周后，将成模大鼠随机分成黄连素高、低剂量组、优降糖组、模型组。给药组灌胃给药4周，正常对照组、模型组同时灌服等容量生理盐水。4周后处死，心脏取血查TC、TG，取主动脉弓部进行病理解剖。结果：经黄连素治疗后，大鼠血脂明显降低，主动脉病变有所改善，与对照组相比差异有显著性（p<0.05）。结论：黄连素可改善2型糖尿病大鼠的脂代谢紊乱。
目的：通過觀察黃連素對2型糖尿病大鼠血脂和主動脈硬化的影響，評價其對2型糖尿病脂代謝紊亂的治療作用。方法：70隻成年雄性SD大鼠，隨機分為正常對照組和實驗組。實驗組大鼠給予高糖高脂飲食餵養8週後，腹腔註射鏈脲佐菌素造2型糖尿病大鼠模型。1週後，將成模大鼠隨機分成黃連素高、低劑量組、優降糖組、模型組。給藥組灌胃給藥4週，正常對照組、模型組同時灌服等容量生理鹽水。4週後處死，心髒取血查TC、TG，取主動脈弓部進行病理解剖。結果：經黃連素治療後，大鼠血脂明顯降低，主動脈病變有所改善，與對照組相比差異有顯著性（p<0.05）。結論：黃連素可改善2型糖尿病大鼠的脂代謝紊亂。
목적：통과관찰황련소대2형당뇨병대서혈지화주동맥경화적영향，평개기대2형당뇨병지대사문란적치료작용。방법：70지성년웅성SD대서，수궤분위정상대조조화실험조。실험조대서급여고당고지음식위양8주후，복강주사련뇨좌균소조2형당뇨병대서모형。1주후，장성모대서수궤분성황련소고、저제량조、우강당조、모형조。급약조관위급약4주，정상대조조、모형조동시관복등용량생리염수。4주후처사，심장취혈사TC、TG，취주동맥궁부진행병리해부。결과：경황련소치료후，대서혈지명현강저，주동맥병변유소개선，여대조조상비차이유현저성（p<0.05）。결론：황련소가개선2형당뇨병대서적지대사문란。
Objective:To observe the effect of berberine on blood lipid and atherosclerosis in type 2 diabetic rats, and evaluate its effect on the treatment of type 2 diabetes and disorders of lipid metabolism. Methods:70 adult male SD rats, were randomly divided into normal control group and experimental group. The experimental rats were given high fat and high sugar diet for 8 weeks, the intraperitoneal injection of streptozotocin model of type 2 diabetic rats. 1 weeks later, the model rats were randomly divided into berberine high, low dose group, glibenclamide group, model group. Treatment groups were oral y administered for 4 weeks, the normal control group, model group were administrated with saline. 4 weeks later, the heart check blood TC, TG, and aortic arch of pathological anatomy. Results:after berberine treatment, blood lipids of rats decreased significantly, aortic lesions improved, compared with the control group with significant difference (p<0.05). Conclusion:Berberine can improve the disorder of lipid metabolism in type 2 diabetic rats.
