中国民康医学
中國民康醫學
중국민강의학
MEDICAL JOURNAL OF CHINSEE PEOPLE HEALTH
2014年
7期
1-2,5
,共3页
抑郁症%文拉法辛缓释片%事件相关电位%认知功能
抑鬱癥%文拉法辛緩釋片%事件相關電位%認知功能
억욱증%문랍법신완석편%사건상관전위%인지공능
Depression%Venlafaxine extended release tablets%Event-related potential%Cognitive function
目的：探讨抗抑郁药文拉法辛缓释片对首发抑郁症患者P300认知电位的影响。方法：共收集32例使用抗抑郁药文拉法辛缓释片的首发抑郁症患者作为研究组，在治疗前及治疗6周后，用24项汉密尔顿抑郁量表( HAMD-24)判定其疗效，进行事件相关电位P300测定判定其认知功能，并选30例与研究组性别、年龄相匹配的健康人作为对照组进行对照研究。结果：治疗6周后，首发抑郁症患者24项汉密尔顿抑郁量表总分明显下降，与治疗前相比，差异有统计学意义(P<0.05)。 P300认知电位测定显示在治疗前，文拉法辛缓释片治疗组与对照组相比较P300认知电位潜伏期延长，波幅降低，差异具有统计学意义(P<0.05)；治疗后，文拉法辛缓释片治疗组P300认知电位潜伏期缩短，波幅增高，与治疗前相比较差异具有统计学意义(P<0.05)。结论：抑郁症患者存在认知障碍，文拉法辛缓释片对抑郁症具有一定的疗效，且对抑郁症患者的认知障碍具有一定的改善作用。
目的：探討抗抑鬱藥文拉法辛緩釋片對首髮抑鬱癥患者P300認知電位的影響。方法：共收集32例使用抗抑鬱藥文拉法辛緩釋片的首髮抑鬱癥患者作為研究組，在治療前及治療6週後，用24項漢密爾頓抑鬱量錶( HAMD-24)判定其療效，進行事件相關電位P300測定判定其認知功能，併選30例與研究組性彆、年齡相匹配的健康人作為對照組進行對照研究。結果：治療6週後，首髮抑鬱癥患者24項漢密爾頓抑鬱量錶總分明顯下降，與治療前相比，差異有統計學意義(P<0.05)。 P300認知電位測定顯示在治療前，文拉法辛緩釋片治療組與對照組相比較P300認知電位潛伏期延長，波幅降低，差異具有統計學意義(P<0.05)；治療後，文拉法辛緩釋片治療組P300認知電位潛伏期縮短，波幅增高，與治療前相比較差異具有統計學意義(P<0.05)。結論：抑鬱癥患者存在認知障礙，文拉法辛緩釋片對抑鬱癥具有一定的療效，且對抑鬱癥患者的認知障礙具有一定的改善作用。
목적：탐토항억욱약문랍법신완석편대수발억욱증환자P300인지전위적영향。방법：공수집32례사용항억욱약문랍법신완석편적수발억욱증환자작위연구조，재치료전급치료6주후，용24항한밀이돈억욱량표( HAMD-24)판정기료효，진행사건상관전위P300측정판정기인지공능，병선30례여연구조성별、년령상필배적건강인작위대조조진행대조연구。결과：치료6주후，수발억욱증환자24항한밀이돈억욱량표총분명현하강，여치료전상비，차이유통계학의의(P<0.05)。 P300인지전위측정현시재치료전，문랍법신완석편치료조여대조조상비교P300인지전위잠복기연장，파폭강저，차이구유통계학의의(P<0.05)；치료후，문랍법신완석편치료조P300인지전위잠복기축단，파폭증고，여치료전상비교차이구유통계학의의(P<0.05)。결론：억욱증환자존재인지장애，문랍법신완석편대억욱증구유일정적료효，차대억욱증환자적인지장애구유일정적개선작용。
Objective:To study effects of venlafaxine extended release tablets on event-related potential P300 in first episode depression patients. Methods:32 patients with first-episode depression were enrolled as research group and treated with venlafaxine extended release tablets. 24-item Hamilton rating scale for depression (HAMD-24) and P300 were used to evaluate the effects of drugs and cognitive function before and 6 weeks after the treatment. 30 healthy individuals were selected as normal control group with the matched sex and age. Results: After 6 weeks' treatment, the scores of HAMD-24 of research group decreased significantly, and the differences were statistically significant before and after the treatment (P<0. 05). Before the treatment, the amplitude and the la-tency of P300 were reduced and prolonged in research group compared with those of normal control group, and the differences were sta-tistically significant (P<0. 05). After the treatment, the amplitude and the latency of P300 increased and were reduced compared with those before the treatment in research group, and the differences were statistically significant (P<0. 05). Conclusions: The patients with depression have cognition deficits. Venlafaxine extended release tablets have therapeutic efficacy and can improve the cognitive function for the depression patients.
