CAJ | 학술논문

奥沙利铂（LOHP）属于新的铂类抗癌药，其铂原子与1，2-二氨环己烷及一个草酸基结合，是单一对映结构体，常用于转移性结直肠癌治疗，或辅助治疗原发性肿瘤完全切除后三期Dukes C结肠癌。随着奥沙利铂在临床的应用日益广泛，其神经毒性反应越来越引起重视，如何预防和减轻奥沙利铂的神经毒性已成为研究重点之一。本文旨在对奥沙利铂神经毒性的治疗研究进展做一综述。
오사리박（LOHP）속우신적박류항암약，기박원자여1，2-이안배기완급일개초산기결합，시단일대영결구체，상용우전이성결직장암치료，혹보조치료원발성종류완전절제후삼기Dukes C결장암。수착오사리박재림상적응용일익엄범，기신경독성반응월래월인기중시，여하예방화감경오사리박적신경독성이성위연구중점지일。본문지재대오사리박신경독성적치료연구진전주일종술。
Oxaliplatin is a new kind of anticancer drug that has good inhibitive effects on cancers. The binding of its platinum atoms with 1, 2-2 ammonia cyclohexane and oxalic acid give rise to a single spherical body structure. It is often used for meta-static colorectal cancer treatment, or adjuvant therapy of primary tumor completely resected phase 3 Dukes C colon cancer. As it is increasingly used in clinic, the oxaliplatin-caused nerve toxicity reaction is getting more and more attention, and it has become one of the research priorities to prevent and reduce such neurotoxicity. In this paper we reviewed the research progress on the treatment of oxaliplatin-induced neurotoxicity.