潍坊医学院学报
濰坊醫學院學報
유방의학원학보
JOURNAL OF WEIFANG MEDICAL COLLEGE
2013年
4期
253-255
,共3页
卵巢癌淋巴结清扫%血小板计数%生存率
卵巢癌淋巴結清掃%血小闆計數%生存率
란소암림파결청소%혈소판계수%생존솔
Lymph node excision%Ophoroma%Survival rate
目的观察晚期卵巢癌行淋巴清扫与未清扫及血小板数量对患者生存率的影响。方法对Ⅲ～Ⅳ期原发性卵巢上皮性癌患者共50例的临床病理资料进行回顾性分析，采用Kaplan－Meier法进行生存时间分析，用Cox风险比例回归模型对影响预后的因素进行多因素分析。结果Ⅲ期卵巢癌患者的3，5年生存率分别为50．00％和33．33％，Ⅳ期的3年和5年的生存率仅为31．25％，12．50％．组织学分级为G2和G3者，3年（43．75％）及5年（31．25％）生存率明显低于G1者（P＜0．05）。血小板计数＞380×109/L 3年和5年生存率分别为47．05％和29．41％，均低于血小板计数≤380×109/L（P＜0．05）。盆腔淋巴清扫组3年和5年的生存率分别为82．35％和64．70％，未行盆腔淋巴结清扫组的3年和5年生存率分别为78．26％和56．52％，2组的生存率无统计学意义。结论手术病理分期、组织学分级、血小板计数是晚期卵巢癌独立的预后因素。行淋巴清扫与否对晚期卵巢癌患者的生存率没有影响。
目的觀察晚期卵巢癌行淋巴清掃與未清掃及血小闆數量對患者生存率的影響。方法對Ⅲ～Ⅳ期原髮性卵巢上皮性癌患者共50例的臨床病理資料進行迴顧性分析，採用Kaplan－Meier法進行生存時間分析，用Cox風險比例迴歸模型對影響預後的因素進行多因素分析。結果Ⅲ期卵巢癌患者的3，5年生存率分彆為50．00％和33．33％，Ⅳ期的3年和5年的生存率僅為31．25％，12．50％．組織學分級為G2和G3者，3年（43．75％）及5年（31．25％）生存率明顯低于G1者（P＜0．05）。血小闆計數＞380×109/L 3年和5年生存率分彆為47．05％和29．41％，均低于血小闆計數≤380×109/L（P＜0．05）。盆腔淋巴清掃組3年和5年的生存率分彆為82．35％和64．70％，未行盆腔淋巴結清掃組的3年和5年生存率分彆為78．26％和56．52％，2組的生存率無統計學意義。結論手術病理分期、組織學分級、血小闆計數是晚期卵巢癌獨立的預後因素。行淋巴清掃與否對晚期卵巢癌患者的生存率沒有影響。
목적관찰만기란소암행림파청소여미청소급혈소판수량대환자생존솔적영향。방법대Ⅲ～Ⅳ기원발성란소상피성암환자공50례적림상병리자료진행회고성분석，채용Kaplan－Meier법진행생존시간분석，용Cox풍험비례회귀모형대영향예후적인소진행다인소분석。결과Ⅲ기란소암환자적3，5년생존솔분별위50．00％화33．33％，Ⅳ기적3년화5년적생존솔부위31．25％，12．50％．조직학분급위G2화G3자，3년（43．75％）급5년（31．25％）생존솔명현저우G1자（P＜0．05）。혈소판계수＞380×109/L 3년화5년생존솔분별위47．05％화29．41％，균저우혈소판계수≤380×109/L（P＜0．05）。분강림파청소조3년화5년적생존솔분별위82．35％화64．70％，미행분강림파결청소조적3년화5년생존솔분별위78．26％화56．52％，2조적생존솔무통계학의의。결론수술병리분기、조직학분급、혈소판계수시만기란소암독립적예후인소。행림파청소여부대만기란소암환자적생존솔몰유영향。
Objective To analyse the relationship between survival blood platelet and lymph node dissection in patients with advanced ovarian cancer .Methods A retrospective analysis was conducted on 50 patients with stage Ⅲ~Ⅳovarian cancer at our department .Outcomes of patients were studied by method of Kaplan-Meier and compared by means of the log-rank test Multivariate Cox regression model ,which were used to assess the correlations between survival and the various prognostic factors .Results Patients with stageⅢhad 3-year overall survival(OS) and 5-year OS of 50. 00%and 33.33%respectively,and patients with stage Ⅳonly had 31.25%in 3-year and 12.50%in 5-year OS.The 3-year OS and 5-year OS in patients with G2/G3 tumor were 43.75%and 31.25%,which were significantly lower than that of patients with G1 tumor.The 3-year OS and 5-year OS in patients with blood platelet >380 ×10 9/L were 47.05%and 29.41%respectively,which were lower than that of patients with blood platelet≤380 ×10 9/L(P<0.05).The 3-year OS and 5-year OS were 82.35% and 64.70% for patients who did undergo lymphadenectomy ,78.26% and 56. 52%for patients who did not undergo lymphadenectomy ,respectively (P >0.05).Conclusions Stage,tumor grade, blood platelet were prognostic factors of patients with advanced ovarian cancer .No significant differences were observed in OS between the patients who did undergo lymphadenectomy and not undergo lymphadenectomy .
