解放军医学院学报
解放軍醫學院學報
해방군의학원학보
Academic Journal of Chinese Pla Medical School
2013年
12期
1265-1268
,共4页
李天志%钱小顺%郭瑞表%孙宝君%刘长庭
李天誌%錢小順%郭瑞錶%孫寶君%劉長庭
리천지%전소순%곽서표%손보군%류장정
肿瘤坏死因子%阻塞性睡眠呼吸暂停低通气综合征%高血压%单核苷酸多态性
腫瘤壞死因子%阻塞性睡眠呼吸暫停低通氣綜閤徵%高血壓%單覈苷痠多態性
종류배사인자%조새성수면호흡잠정저통기종합정%고혈압%단핵감산다태성
TNF-α%obstructive sleep apnea hypopnea syndrome%hypertension%single nucleotidepolymorphisms
目的：探讨TNF-α基因多态性与阻塞性睡眠呼吸低通气暂停综合征(obstructive sleep apnea hypopnea syndrome， OSAHS)合并高血压的关系。方法2009-2012年于本院行多导睡眠检查，结果为重度OSAHS的300例男性患者，其中OSAHS伴高血压者145例，并随机抽取100例健康男性对照，采用基因测序的方法，检测TNF-α启动区基因-308G＞A和-863C＞A的基因多态性。采用R×C列联表χ2检验统计OSAHS伴高血压组、单纯OSAHS组以及健康对照组之间TNF-α基因多态性的关系。结果 OSAHS合并高血压组TNF-α-308GA型基因频率分布明显降低，为4.1%，而单纯OSAHS组和健康对照组GA型基因所占比例增高，分别为11.6%和12.0%。TNF-α-863基因类型以CC型为主，各组之间的基因频率分布差异无统计学意义。结论 TNF-α-308GA型基因可能通过减少TNF-α表达而对OSAHS合并高血压具有保护作用，TNF-α-308GA型与OSAHS伴高血压存在一定关联。
目的：探討TNF-α基因多態性與阻塞性睡眠呼吸低通氣暫停綜閤徵(obstructive sleep apnea hypopnea syndrome， OSAHS)閤併高血壓的關繫。方法2009-2012年于本院行多導睡眠檢查，結果為重度OSAHS的300例男性患者，其中OSAHS伴高血壓者145例，併隨機抽取100例健康男性對照，採用基因測序的方法，檢測TNF-α啟動區基因-308G＞A和-863C＞A的基因多態性。採用R×C列聯錶χ2檢驗統計OSAHS伴高血壓組、單純OSAHS組以及健康對照組之間TNF-α基因多態性的關繫。結果 OSAHS閤併高血壓組TNF-α-308GA型基因頻率分佈明顯降低，為4.1%，而單純OSAHS組和健康對照組GA型基因所佔比例增高，分彆為11.6%和12.0%。TNF-α-863基因類型以CC型為主，各組之間的基因頻率分佈差異無統計學意義。結論 TNF-α-308GA型基因可能通過減少TNF-α錶達而對OSAHS閤併高血壓具有保護作用，TNF-α-308GA型與OSAHS伴高血壓存在一定關聯。
목적：탐토TNF-α기인다태성여조새성수면호흡저통기잠정종합정(obstructive sleep apnea hypopnea syndrome， OSAHS)합병고혈압적관계。방법2009-2012년우본원행다도수면검사，결과위중도OSAHS적300례남성환자，기중OSAHS반고혈압자145례，병수궤추취100례건강남성대조，채용기인측서적방법，검측TNF-α계동구기인-308G＞A화-863C＞A적기인다태성。채용R×C렬련표χ2검험통계OSAHS반고혈압조、단순OSAHS조이급건강대조조지간TNF-α기인다태성적관계。결과 OSAHS합병고혈압조TNF-α-308GA형기인빈솔분포명현강저，위4.1%，이단순OSAHS조화건강대조조GA형기인소점비례증고，분별위11.6%화12.0%。TNF-α-863기인류형이CC형위주，각조지간적기인빈솔분포차이무통계학의의。결론 TNF-α-308GA형기인가능통과감소TNF-α표체이대OSAHS합병고혈압구유보호작용，TNF-α-308GA형여OSAHS반고혈압존재일정관련。
Objective To study the relation between TNF-α polymorphism and obstructive sleep apnea hypopnea syndrome (OSAHS) accompanying hypertension.Methods Three hundred severe OSAHS male patients who underwent sleep examination in our hospital from 2009 to 2012 were included in this study. Of these patients, 145 with hypertension served as a hypertension group and 100 randomly selected healthy subjects served as a control group. Their promoter gene (-308G>A and -863C>A) polymorphism was detected by gene sequencing. Relation between TNF-α polymorphism and OSAHS was analyzed byχ2 test in OSAHS patients with hypertension, OSAHS patients and controls according to the R×C scale.Results The frequency of TNF-α-308GA was significantly lower in OSAHS patients with hypertension than in those without hypertension and healthy controls (4.1%vs 11.6% and 12.0%). No significant difference was found in the TNF-α-308 mainly manifested as the CC genotype among the 3 groups.Conclusion TNF-α-308GA can protect the OSAHS patients with hypertension by reducing TNF-α expression and is related with OSAHS accompanying hypertension.
