CAJ | 학술논문

目的：探讨14-3-3ζ和p-Akt蛋白异常表达与食管癌之间的关系。方法应用免疫组织化学技术检测50例食管鳞癌组织及癌旁组织中14-3-3ζ和p-Akt蛋白的表达。结果14-3-3ζ和p-Akt蛋白在食管鳞癌中阳性表达率均大于癌旁正常食管组织；且与组织分化程度和淋巴结转移密切相关，而与患者的年龄和肿瘤浸润深度无相关性。经Spearman相关性分析，食管鳞癌中14-3-3ζ与p-Akt阳性表达呈显著相关。结论14-3-3ζ和p-Akt参与了食管癌的发生和发展过程。
목적：탐토14-3-3ζ화p-Akt단백이상표체여식관암지간적관계。방법응용면역조직화학기술검측50례식관린암조직급암방조직중14-3-3ζ화p-Akt단백적표체。결과14-3-3ζ화p-Akt단백재식관린암중양성표체솔균대우암방정상식관조직；차여조직분화정도화림파결전이밀절상관，이여환자적년령화종류침윤심도무상관성。경Spearman상관성분석，식관린암중14-3-3ζ여p-Akt양성표체정현저상관。결론14-3-3ζ화p-Akt삼여료식관암적발생화발전과정。
Objective To study the relation between 14-3-3ζ and p-Akt expression and esophageal squamous carcinoma. Methods Expressions of 14-3-3ζ and p-Akt in esophageal squamous carcinoma and its adjacent tissues were detected by immunohistochemistry.Results The expression level of 14-3-3ζ and p-Akt was higher in esophageal squamous carcinoma tissue than in its adjacent normal tissue, and was closely related with the histological differentiation and lymphatic metastasis but not related with the age of patients and the tumor invasion depth. Spearman correlation analysis showed that the expression level of 14-3-3ζ and p-Akt was significantly related with esophageal squamous carcinoma. Conclusion 14-3-3ζ and p-Akt are involved in the occurrence and development of esophageal squamous carcinoma.