CAJ | 학술논문

同步放化疗治疗中晚期宫颈癌较单纯放疗能提高总生存率和无进展生存率，降低复发率，改善预后。同步放化疗不是简单的放疗与化疗相加，化疗不仅能杀死癌细胞，杀灭肿瘤亚临床病灶，同时对放疗有增敏作用。同步放化疗机制可能是化疗抑制肿瘤细胞放疗后损伤的修复，减少对放疗不敏感的乏氧细胞的比例和促使肿瘤细胞同步化进入对放疗敏感的细胞周期。目前大多数研究者认为使用以顺铂为基础的同步放化疗方案效果更佳。同步放化疗较单纯放疗的毒副作用相对较大，具体使用仍处于摸索阶段。
동보방화료치료중만기궁경암교단순방료능제고총생존솔화무진전생존솔，강저복발솔，개선예후。동보방화료불시간단적방료여화료상가，화료불부능살사암세포，살멸종류아림상병조，동시대방료유증민작용。동보방화료궤제가능시화료억제종류세포방료후손상적수복，감소대방료불민감적핍양세포적비례화촉사종류세포동보화진입대방료민감적세포주기。목전대다수연구자인위사용이순박위기출적동보방화료방안효과경가。동보방화료교단순방료적독부작용상대교대，구체사용잉처우모색계단。
The chemoradiotherapy for medium-term and advanced cervical cancer has better efficacy than the pure radiotherapy to improve overall survival rate and progression free survival rate ,it can reduce the recurrence rate and improve prognosis .Chemoradiotherapy is not a simple radiotherapy combined with chemotherapy and chemothera -py can not only kill cancer cells and tumor subclinical lesions , also increase sensitivity of cancer cells to radiothera-py.Chemoradiotherapy mechanism may be:chemotherapy could inhibit tumor cells′radiation damage repair , reduce the proportion of hypoxic cells which is not sensitive to radiotherapy and promote the tumor cells entering into the radi -ation sensitive cell cycle synchronously .Most think that the effect of concurrent chemoradiotherapy program based on cisplatin is better , concurrent chemoradiotherapy has more side effects than alone radiotherapy ,and its concrete usage is still in groping stage .