CAJ | 학술논문

目的：比较采用不同浓度罗哌卡因行坐骨神经阻滞时所需的半数有效剂量。方法：择期单侧足踝手术病人30例随机进入高浓度组( H组，n=15)或低浓度组( L组，n=15)。采用Probit概率单位回归法计算不同浓度罗哌卡因行坐骨神经阻滞的半数有效剂量。结果：高浓度组的半数有效剂量10.18 mL，低浓度组的半数有效剂量11 mL（P＞0.05）。结论：采用0.375%和0.5%两种不同浓度罗哌卡因行坐骨神经阻滞时所需的半数有效剂量没有显著性差异。
목적：비교채용불동농도라고잡인행좌골신경조체시소수적반수유효제량。방법：택기단측족과수술병인30례수궤진입고농도조( H조，n=15)혹저농도조( L조，n=15)。채용Probit개솔단위회귀법계산불동농도라고잡인행좌골신경조체적반수유효제량。결과：고농도조적반수유효제량10.18 mL，저농도조적반수유효제량11 mL（P＞0.05）。결론：채용0.375%화0.5%량충불동농도라고잡인행좌골신경조체시소수적반수유효제량몰유현저성차이。
Objective To compare half effective dose(ED50) of different ropivacaine for sciatic nerve block. Methods Thirty patients scheduled for foot or ankle surgery under the sciatic nerve block were randomly di-vided into the following two groups, one was high concentration group(group H ,n=15), the other was low concen-tration group(group L,n=15). Both groups of the patients were received the parasacal sciatic nerve block with the aid of nerve stimulator.The initial dose of both groups were 14 mL in the first patient and the ratio between the 2 successive doses was 1.2.The ED50 and 95% confidence interval(CI)of ropivacaine were calculated by Probit Regeression method. Results The ED50 and the 95% CI of 0.375%ropivacaine in patients of group L was 11 mL(9.46 mL~12.53 mL), while those of 0.5% ropivacaine in patients of the group H was 10.18 mL(8.67 mL 1~1.17 mL). There were no significant difference between the two groups. (P>0.05). Conclusion The ED50 of 0.375%and 0.5% ropivacaine for sciatic nerve block has no significant difference..