CAJ | 학술논문

目的：探讨新疆维吾尔族高血压患者颈动脉斑块与短时血压变异的关系。方法选取2010年2月-2013年6月在新疆医科大学第一附属医院心脏中心高血压科就诊并确诊的维吾尔族高血压患者463例，根据彩色多普勒超声诊断将其分为斑块组和无斑块组。检侧患者空腹血糖、三酰甘油、总胆固醇、高密度脂蛋白胆固醇（HDL - C）、低密度脂蛋白胆固醇（LDL - C）、载脂蛋白 A1、载脂蛋白 B，并记录24 h 平均收缩压、24 h 平均舒张压、24 h 收缩压变异、24 h 舒张压变异、24 h 平均心率。对颈动脉斑块的相关危险因素进行单因素分析和多因素 Logis-tic 回归分析。结果斑块组与无斑块组的年龄、服降压药、高血压病程、体质指数（BMI）、总胆固醇、LDL - C 、24 h 平均收缩压、24 h 平均舒张压、24 h 收缩压变异、24 h 平均心率比较，差异有统计学意义（P ﹤0.05）。多因素 Lo-gistic 回归分析显示，年龄、24 h 收缩压变异是颈动脉斑块的独立危险因素〔OR（95% CI）＝1.086（1.059，1.114）、1.108（1.035，1.187），P ﹤0.05〕。结论新疆维吾尔族高血压患者颈动脉斑块与短时血压变异，尤其是短时收缩压变异独立相关，临床医生应重视高血压患者的短时血压变异。
목적：탐토신강유오이족고혈압환자경동맥반괴여단시혈압변이적관계。방법선취2010년2월-2013년6월재신강의과대학제일부속의원심장중심고혈압과취진병학진적유오이족고혈압환자463례，근거채색다보륵초성진단장기분위반괴조화무반괴조。검측환자공복혈당、삼선감유、총담고순、고밀도지단백담고순（HDL - C）、저밀도지단백담고순（LDL - C）、재지단백 A1、재지단백 B，병기록24 h 평균수축압、24 h 평균서장압、24 h 수축압변이、24 h 서장압변이、24 h 평균심솔。대경동맥반괴적상관위험인소진행단인소분석화다인소 Logis-tic 회귀분석。결과반괴조여무반괴조적년령、복강압약、고혈압병정、체질지수（BMI）、총담고순、LDL - C 、24 h 평균수축압、24 h 평균서장압、24 h 수축압변이、24 h 평균심솔비교，차이유통계학의의（P ﹤0.05）。다인소 Lo-gistic 회귀분석현시，년령、24 h 수축압변이시경동맥반괴적독립위험인소〔OR（95% CI）＝1.086（1.059，1.114）、1.108（1.035，1.187），P ﹤0.05〕。결론신강유오이족고혈압환자경동맥반괴여단시혈압변이，우기시단시수축압변이독립상관，림상의생응중시고혈압환자적단시혈압변이。
Objective To investigate the relationship of carotid artery plaque(CAP)to short - term blood pressure variability(BPV)and its related risk factors. Methods A total of 463 in - patients with essential hypertension(EH)treated in department of hypertension the First Teaching Hospital of Xinjiang Medical University from February 2010 to June 2013 were di-vided,according to color Doppler ultrasound,into groups plaque,non - plaque. Fasting blood glucose(FBG),triaculglycerol (TG), total cholesterol ( TC ), high density lipoprotein cholesterol ( HDL - C ), low density lipoprotein cholesterol (LDL - C),apolipoprotein A1,apolipoprotein B were determined and 24 h mean diastolic blood pressure(DBP),24 h mean systolic blood pressure(SBP),24 h DBP variability,24 h SBP variability,24 h mean heart rate(HR)recorded. Univarate and multivariate Logistic regression analyses were carried out on the related risk factors of CAP. Results There were significant differences in age,antihypertensive drug administration,hypertension duration,BMI,TC,LDL - C,24 h mean SBP,24 h mean DBP,24 h SBP variability,24 h mean HR between 2 groups( P ﹤ 0. 05). Multivariate Logistic regression analysis showed that age,24 h SBP variability were independent risk factors of CAP〔 OR(95% CI) = 1. 086(1. 059,1. 114), 1. 108(1. 035,1. 187),P ﹤ 0. 05〕. Conclusion CAP is correlate independently with short - term BP variability,especially that of SBP in Uyghur hypertension patients. Clinicians should pay attention to short - term variability of BP in hypertension pa-tients.