CAJ | 학술논문

目的探讨妊娠期高血压疾病(HDCP)患者血清转化生长因子1(TGF-β1)和肿瘤坏死因子-α(TNF-α)的变化及临床意义.方法采用酶联免疫吸附反应(ELISA)方法检测50例HDCP患者和30例正常晚孕期妊娠妇女(对照组)分娩前血清中TGF-β1和TNF-α水平.50例HDCP患者根据病情严重程度分为三个亚组:妊娠期高血压组、轻度子痫前期组、重度子痫前期组.结果 HDCP组患者血清TGF-β1和TNF-α水平显著高于对照组(t=13.283、13.607,均P＜0.05).随HDCP患者病情加重,血清TGF-β1和TNF-α水平呈逐渐上升趋势,HDCP各亚组之间血清TGF-β1和TNF-α水平差异均有统计学意义(均P＜0.05).相关性分析表明,血清TGF-β1、TNF-α水平与HDCP病情呈正相关性(r=0.575、0.512,均P＜0.05),血清TGF-β1和TNF-α水平之间呈正相关(r=0.515,P＜0.05).结论 HDCP患者血清中存在TGF-β1、TNF-α高表达,血清TGF-β1、TNF-α水平可以反映HDCP患者病情的变化与发展,TGF-β1、TNF-α表达异常可能与HDCP滋养细胞功能低下有关.
목적 탐토임신기고혈압질병(HDCP)환자혈청전화생장인자1(TGF-β1)화종류배사인자-α(TNF-α)적변화급림상의의.방법 채용매련면역흡부반응(ELISA)방법검측50례HDCP환자화30례정상만잉기임신부녀(대조조)분면전혈청중TGF-β1화TNF-α수평.50례HDCP환자근거병정엄중정도분위삼개아조:임신기고혈압조、경도자간전기조、중도자간전기조.결과 HDCP조환자혈청TGF-β1화TNF-α수평현저고우대조조(t=13.283、13.607,균P＜0.05).수HDCP환자병정가중,혈청TGF-β1화TNF-α수평정축점상승추세,HDCP각아조지간혈청TGF-β1화TNF-α수평차이균유통계학의의(균P＜0.05).상관성분석표명,혈청TGF-β1、TNF-α수평여HDCP병정정정상관성(r=0.575、0.512,균P＜0.05),혈청TGF-β1화TNF-α수평지간정정상관(r=0.515,P＜0.05).결론 HDCP환자혈청중존재TGF-β1、TNF-α고표체,혈청TGF-β1、TNF-α수평가이반영HDCP환자병정적변화여발전,TGF-β1、TNF-α표체이상가능여HDCP자양세포공능저하유관.
Objective To study the expression and clinical significance of serum levels of transforming growth factor-31 (TGF-β1) and tumor necrosis factor-alpha(TNF-α) in patients with hypertensive disorder complicating pregnancy(HDCP).Methods The serum levels of TGF-β1 and TNF-αin 50 cases with HDCP and 30 cases of normal third trimester pregnant women(control group) were detected by ELISA.50 cases with HDCP were divided into gestational hypertension group,mild preeclampsia group and severe preeclampsia group according to the severity of HDCP.Results The serum levels of TGF-β1 and TNF-α in HDCP patients were significantly higher than the control group (t =13.283,13.607,all P ＜ 0.05).The serum levels of TGF-β1 and TNF-α gradually increased with the aggravating of HDCP disease,the serum levels of TGF-β1 and TNF-αwere significantly different among the three subgroups of HDCP(P ＜ 0.05).The correlation analysis showed that the serum levels of TGF-β1,TNF-α were positively correlated with the severity of HDCP (r =0.575,0.512,all P ＜ 0.05),there was significantly positive correlation between the serum TGF-β1 and TNF-α(r =0.515,P ＜0.05).Conclusion The serum levels of TGF-β1 and TNF-α were high in the HDCP patients,the high levels of TGF-β1 and TNF-α can reflect the changes and development of HDCP disease.The abnormal levels of TGF-β1 and TNF-α may be associate with dysfunction of trophoblast cell.