CAJ | 학술논문

目的：探究不同剂量阿托伐他汀对慢性心衰（ CHF）大鼠炎症反应及心功能的影响。方法将60只实验大鼠随机分为正常对照组（CON）、心衰模型组（CHF）、低剂量阿托伐他汀组（SD-ATO）、高剂量阿托伐他汀组（HD-ATO）。采用腹腔注射阿霉素（ ADR）法制造慢性心衰大鼠模型，SD-ATO组及HD-ATO组在首次注射ADR时即给予不同剂量的阿托伐他汀，剂量分别为5mg/kg· d，20mg/kg· d，CON组给予等量生理盐水。6周后，超声心动图观察各组大鼠心脏结构及功能的变化，ELISA法测定各组血清hs-CRP，BNP水平，同时观察大鼠心脏形态学改变。结果与CHF组相比，HD-ATO组大鼠心脏重量指数降低，心脏彩超表现有所改善，血清hs-CRP，BNP水平显著降低（P＜0．01）。 SD-ATO组仅hs-CRP水平降低（P＜0．01），其余各项指标较CHF组无明显改变。结论阿托伐他汀能减轻慢性心衰过程中的炎症反应，改善心脏结构及功能，高剂量阿托伐他汀较低剂量作用更明显。
목적：탐구불동제량아탁벌타정대만성심쇠（ CHF）대서염증반응급심공능적영향。방법장60지실험대서수궤분위정상대조조（CON）、심쇠모형조（CHF）、저제량아탁벌타정조（SD-ATO）、고제량아탁벌타정조（HD-ATO）。채용복강주사아매소（ ADR）법제조만성심쇠대서모형，SD-ATO조급HD-ATO조재수차주사ADR시즉급여불동제량적아탁벌타정，제량분별위5mg/kg· d，20mg/kg· d，CON조급여등량생리염수。6주후，초성심동도관찰각조대서심장결구급공능적변화，ELISA법측정각조혈청hs-CRP，BNP수평，동시관찰대서심장형태학개변。결과여CHF조상비，HD-ATO조대서심장중량지수강저，심장채초표현유소개선，혈청hs-CRP，BNP수평현저강저（P＜0．01）。 SD-ATO조부hs-CRP수평강저（P＜0．01），기여각항지표교CHF조무명현개변。결론아탁벌타정능감경만성심쇠과정중적염증반응，개선심장결구급공능，고제량아탁벌타정교저제량작용경명현。
Objective To investigate atorvastatin in dose-dependently affects inflammation and cardiac function in chronic heart failure(CHF) rats.Methods Sixty rats were randomized to control group (CON),chronic heart failure group (CHF),small-dose atorvastatin group( SD-ATO) ,and the high-dose atorvastatin group ( HD-ATO) .CHF model were induced by intraperitoneal injection of adriamycin .The SD-ATO and HD-ATO groups were injected varying doses of atorvastatin together with adriamycin for the first time ,5mg/kg· d for SD-ATO, 20mg/kg· d for HD-ATO.The control group were injected the same doses of normal saline .After 6 weeks,the change of cardiac structure and function by echocardiograph were observed .Monitoring the level of hs-CRP,BNP in serum by the method of ELISA and evaluating the varia-tion of myocardium in Morphology were performed .Results Compared with the CHF ,heart weight index in HD-ATO group was significantly decreased(P<0.01),echocardiograph performance was improved ,and the level of hs-CRP,BNP in serum were significantly decreased (P<0.01).In SD-ATO group,only the hs-CRP level was lower than that of CHF group (P<0.01),other indexes had no significant difference with CHF group.Conclusion Atorvastatin could reduce inflammation and improve the cardiac structure and function .Compared with small doses,high doses atorvastatin have more obvious effect .