CAJ | 학술논문

目的：探讨结核蛋白芯片检测对诊断肺结核及肺外结核的价值。方法使用蛋白芯片系统检测血清结核抗体的病例共4765例,其中肺结核334例,肺外结核83例,肺结核并肺外结核69例，非结核病4279例。我们采用的蛋白芯片包含了结核分枝杆菌(MTB)中5种成分，即ESAT-6、CFP10、LAM、38KD和16KD。结果334例肺结核中227例结核抗体阳性,83例肺外结核中50例阳性,69例肺结核并肺外结核中51例阳性，4279例非结核病797例阳性,结核蛋白芯片检测肺结核的阳性率为67.96%,肺外结核的阳性率为60.24%,肺结核并肺外结核的阳性率为73.91%，非结核病的阳性率为18.62%。结论结核蛋白芯片是对肺结核及肺外结核的辅助诊断有重要价值。但在淋巴结结核、结核性胸膜炎中阳性率偏低,敏感性稍差。
목적：탐토결핵단백심편검측대진단폐결핵급폐외결핵적개치。방법사용단백심편계통검측혈청결핵항체적병례공4765례,기중폐결핵334례,폐외결핵83례,폐결핵병폐외결핵69례，비결핵병4279례。아문채용적단백심편포함료결핵분지간균(MTB)중5충성분，즉ESAT-6、CFP10、LAM、38KD화16KD。결과334례폐결핵중227례결핵항체양성,83례폐외결핵중50례양성,69례폐결핵병폐외결핵중51례양성，4279례비결핵병797례양성,결핵단백심편검측폐결핵적양성솔위67.96%,폐외결핵적양성솔위60.24%,폐결핵병폐외결핵적양성솔위73.91%，비결핵병적양성솔위18.62%。결론결핵단백심편시대폐결핵급폐외결핵적보조진단유중요개치。단재림파결결핵、결핵성흉막염중양성솔편저,민감성초차。
Objective To explore the diagnosis value of tuberculosis protein chip for pulmonary and extra pulmonary tuberculosis(TB). Methods The serum tuberculosis antibodies were detected by using protein chip system in 4765 cases, including 334 cases of pulmonary tuberculosis, 83 cases of extra pulmonary tuberculosis, 69 cases of pulmonary tuberculosis and extra pulmonary tuberculosis, 4279 cases of non tuberculosis. The protein chip we used contain 5 components of Mycobacterium tuberculosis, namely ESAT-6、CFP10、LAM、38KD and 16KD. Results The TB antibody was detected positive in 227 of 334 pulmonary TB cases,positive in 50 of 83 extra pulmonary TB cases, positive in 51 of 69 pulmonary TB and extra pulmonary TB cases, and positive in 797 of 4279 non-TB cases. The positive rate of detection of tuberculosis antibody using tuberculosis protein chip in pulmonary tuberculosis group was 67.96%. The positive rate in extra pulmonary tuberculosis group was 60.24%. The positive rate in pulmonary and extra pulmonary group was 73.91%. The positive rate in non-TB group was 18.62%. Conclusion The TB protein chip is a fast, easy and effective method for diagnosing the pulmonary TB and extra pulmonary TB with good specificity, but it is less sensitive in the diagnosis of lymphoid tuberculosis and tuberculous pleurisy.