中国中西医结合肾病杂志
中國中西醫結閤腎病雜誌
중국중서의결합신병잡지
CHINESE JOURNAL OF INTEGRATED TRADITIONAL AND WESTERN NEPHROLOGY
2014年
9期
784-787
,共4页
龚学忠%汤晓春%王骞%王跃荣%周家俊
龔學忠%湯曉春%王鶱%王躍榮%週傢俊
공학충%탕효춘%왕건%왕약영%주가준
川黄方%慢性肾脏病合并急性肾损伤%前列腺素E1
川黃方%慢性腎髒病閤併急性腎損傷%前列腺素E1
천황방%만성신장병합병급성신손상%전렬선소E1
Chuanhuang fang decoction%Acute kidney injury ( AKI) on Chronic Kidney Disease ( CKD)%Lipo PGE1
目的:观察川黄方联合前列腺素E1(凯时)治疗脾肾气虚、毒瘀互结型2~4期慢性肾脏病( chronic kidney disease,CKD)合并急性肾损伤( acute kidney injury,AKI)的临床疗效。方法:符合纳入标准病例60例,随机分为2组,其中川黄方加凯时组(治疗组)29例、凯时组(对照组)31例,疗程均为2周。观察两组治疗前后的中医证候积分、血肌酐( Scr)、血尿素氮( BUN)、血尿酸( UA)、肾小球滤过率( eGFR),并统计临床总有效率。结果:与治疗前相比,两组均能有效降低Scr、BUN、UA(P<0.05或P<0.01),提高eGFR(P<0.05),但治疗组较对照组在Scr、BUN、eGFR改善方面更为明显(P<0.05或P<0.01)。另外,治疗组取得75.86%的总有效率,显著优于对照组(35.48%,P<0.01),中医证候积分改善方面治疗组亦优于对照组(P<0.01)。结论:川黄方联合凯时能有效减轻A on C患者肾损伤、促进肾功能恢复,并改善中医证候群,优于单用凯时治疗。
目的:觀察川黃方聯閤前列腺素E1(凱時)治療脾腎氣虛、毒瘀互結型2~4期慢性腎髒病( chronic kidney disease,CKD)閤併急性腎損傷( acute kidney injury,AKI)的臨床療效。方法:符閤納入標準病例60例,隨機分為2組,其中川黃方加凱時組(治療組)29例、凱時組(對照組)31例,療程均為2週。觀察兩組治療前後的中醫證候積分、血肌酐( Scr)、血尿素氮( BUN)、血尿痠( UA)、腎小毬濾過率( eGFR),併統計臨床總有效率。結果:與治療前相比,兩組均能有效降低Scr、BUN、UA(P<0.05或P<0.01),提高eGFR(P<0.05),但治療組較對照組在Scr、BUN、eGFR改善方麵更為明顯(P<0.05或P<0.01)。另外,治療組取得75.86%的總有效率,顯著優于對照組(35.48%,P<0.01),中醫證候積分改善方麵治療組亦優于對照組(P<0.01)。結論:川黃方聯閤凱時能有效減輕A on C患者腎損傷、促進腎功能恢複,併改善中醫證候群,優于單用凱時治療。
목적:관찰천황방연합전렬선소E1(개시)치료비신기허、독어호결형2~4기만성신장병( chronic kidney disease,CKD)합병급성신손상( acute kidney injury,AKI)적림상료효。방법:부합납입표준병례60례,수궤분위2조,기중천황방가개시조(치료조)29례、개시조(대조조)31례,료정균위2주。관찰량조치료전후적중의증후적분、혈기항( Scr)、혈뇨소담( BUN)、혈뇨산( UA)、신소구려과솔( eGFR),병통계림상총유효솔。결과:여치료전상비,량조균능유효강저Scr、BUN、UA(P<0.05혹P<0.01),제고eGFR(P<0.05),단치료조교대조조재Scr、BUN、eGFR개선방면경위명현(P<0.05혹P<0.01)。령외,치료조취득75.86%적총유효솔,현저우우대조조(35.48%,P<0.01),중의증후적분개선방면치료조역우우대조조(P<0.01)。결론:천황방연합개시능유효감경A on C환자신손상、촉진신공능회복,병개선중의증후군,우우단용개시치료。
Objective:Observe the clinical efficacy of Chuanhuang Fang combined with Lipo PGE1 in treating acute kidney injury ( AKI) on phase 2-4 Chronic Kidney Disease ( CKD) patients. Methods:60 patients who were outpatient and hospitalized in Shanghai Municipal Hospital of Traditional Chinese Medicine were randomly divided into 2 groups, including treatment group (29 ca-ses) and control group (31 cases). All patients were given the same diet care and basic treatment. Treatment group treated with Chuanhuang Fang decoction combined with Lipo PGE1 while control group treated with Lipo PGE1, and continuous observation for two weeks. TCM symptom scores, serum creatinine ( Scr) , blood urea nitrogen ( BUN) , uric acid ( UA) , and glomerular filtration rate ( GFR, MDRD equation) was observed and compared before and after treatment, furthermore, total efficiency was calculated and ana-lyzed. Results:After two weeks treatment, two groups reduced Scr, BUN, UA and TCM symptom scores (P<0. 05 or P<0. 01), increase the glomerular filtration rate (P<0. 05), while treatment group showed better efficiency (P<0. 05). Treatment group a-chieved 75. 86% of the total efficiency, superior Lipo PGE1 group (35. 48%) (P<0. 01). Conclusion:Treatment group can relieve TCM symptoms and protecting renal function in acute kidney injury on phase 2-4 CKD patients, which is better than control group, and thus Chuanhuang Decoction might be a potentially useful method for A on C patients clinical treatment.