CAJ | 학술논문

目的：探讨婴幼儿罹患人博卡病毒(HBoV)、肺炎支原体(MP)肺炎后的肺功能变化及其临床意义。方法选取2013年1月至2013年10月期间因支气管肺炎住院治疗的<3岁的婴幼儿140例，其中HBoV阳性64例、MP阳性76例；另选正常同年龄婴幼儿38例，采用德国耶格MasterScope肺功能仪进行肺功能检测，分析比较其检测指标及潮气呼吸流速容量环形态。结果 HBoV及MP支气管肺炎婴幼儿的到达峰流速时间/呼气时间(TPTEF/TE)、到达峰流速时呼出气量/呼气容积(VPTEF/VE)、剩余25%潮气量时呼气流速(TEF25%)和剩余25%潮气量时的呼气流速/呼气峰速(25/PF)都明显低于正常同年龄对照组，差异有统计学意义(P均<0.05)；HBoV、MP支气管肺炎婴幼儿之间上述指标的差异则无统计学意义(P均>0.05)。支气管肺炎与正常对照婴幼儿的潮气呼吸流速容量环(TBFVL)形态均有改变，都表现为呼气相高峰提前，呼气相降支呈波谷样凹陷，其中支气管肺炎婴幼儿峰度稍有降低。结论 HBoV和MP感染所引起的支气管肺炎可致婴幼儿肺功能损害，且都表现为小气道阻塞性通气功能障碍；在直观的TBFVL表现为呼气高峰左移，降支波谷样凹陷。
목적：탐토영유인리환인박잡병독(HBoV)、폐염지원체(MP)폐염후적폐공능변화급기림상의의。방법선취2013년1월지2013년10월기간인지기관폐염주원치료적<3세적영유인140례，기중HBoV양성64례、MP양성76례；령선정상동년령영유인38례，채용덕국야격MasterScope폐공능의진행폐공능검측，분석비교기검측지표급조기호흡류속용량배형태。결과 HBoV급MP지기관폐염영유인적도체봉류속시간/호기시간(TPTEF/TE)、도체봉류속시호출기량/호기용적(VPTEF/VE)、잉여25%조기량시호기류속(TEF25%)화잉여25%조기량시적호기류속/호기봉속(25/PF)도명현저우정상동년령대조조，차이유통계학의의(P균<0.05)；HBoV、MP지기관폐염영유인지간상술지표적차이칙무통계학의의(P균>0.05)。지기관폐염여정상대조영유인적조기호흡류속용량배(TBFVL)형태균유개변，도표현위호기상고봉제전，호기상강지정파곡양요함，기중지기관폐염영유인봉도초유강저。결론 HBoV화MP감염소인기적지기관폐염가치영유인폐공능손해，차도표현위소기도조새성통기공능장애；재직관적TBFVL표현위호기고봉좌이，강지파곡양요함。
Objective To discuss the pulmonary function change in infants with human bocavirus (HBoV) pneumonia or mycoplasma pneumonia (MP) and its clinical signiifcance. Methods One hundred and forty infants under 3 years old who were admitted due to pulmonary infection were recruited from January, 2013 to October, 2013. Among them, HBoV-DNA was detected in 64 cases, and MP-DNA was detected in 76 cases. Thirty eight normal age-matched infants were selected as controls. The shape of tidal breathing lfow-volume loops (TBFVLs) and change of every index were measured with a Pulmonary Testing System (Jaeger MasterScope). Results The ratio of time to peak tidal expiratory lfow (PTEF) to total expiratory time (TPTEF/TE), the ratio of VPTEF to expiratory volume (VPTEF/VE), tidal expiratory lfow at 25%of the remaining tidal volume (TEF25%) and the ratio of TEF25%to PTEF (25/PF) were signiifcantly decreased in infants with HBoV and MP infection as compared with healthy infants (P<0.05). However, there was no signiifcant difference of the above indices between infants with HBoV and MP infection (P>0.05). The shape of TBFVLs in infants with HBoV and MP pneumonia was changed and characterized by left-shifted PTEF and trough-like concave in descending limb. The PTEF was decreased in infants with pulmonary infection. Conclusions HBoV or MP infection results in impaired pulmonary function with manifestations of obstruction in small airway. The shape of TBFVLs in infants with HBoV and MP pneumonia is characterized by left-shifted PTEF and trough-like concave in descending limb.