临床儿科杂志
臨床兒科雜誌
림상인과잡지
2014年
9期
846-849
,共4页
罗开菊%陈平洋%赵亚凡%贺鸣凤
囉開菊%陳平洋%趙亞凡%賀鳴鳳
라개국%진평양%조아범%하명봉
瘦素%骨声波传导速度%适于胎龄儿
瘦素%骨聲波傳導速度%適于胎齡兒
수소%골성파전도속도%괄우태령인
leptin%bone speed of sound%appropriate-for-gestational-age neonate
目的：探讨新生适于胎龄儿血清瘦素、骨声波传导速度(SOS)随胎龄的变化，以及瘦素与新生儿骨SOS的关系。方法共收集65例新生适于胎龄儿，根据胎龄分为早期早产儿组(胎龄31~34周，14例)，晚期早产儿组(胎龄34~37周，13例)，足月儿组(胎龄≥37周，38例)。所有研究对象均测量出生体质量、身长、小腿长度，采用Ponderal指数(PI)估测新生儿营养状态，采用weststrate公式(F%)估测新生儿体脂含量。生后7 d内采集静脉血测定血清瘦素水平，同时采用超声定量技术测量左侧胫骨SOS。结果三组新生儿胎龄、出生体质量、身长、小腿长度、F%、PI、血清瘦素与骨SOS的差异均有统计学意义(F=11.90~140.20，P均<0.01)；各变量均随胎龄增大而增大(P均<0.05)。Pearson相关分析提示，除足月儿身长、PI外，三组新生儿的血清瘦素与其胎龄、出生体质量、身长、PI、F%呈显著正相关(r=0.36~0.78， P均<0.05)。三组新生儿骨SOS分别与其瘦素、胎龄、出生体质量及小腿长度呈显著正相关(r=0.33~0.76，P均<0.05)。进一步多元线性逐步回归分析发现，仅新生儿的胎龄(β=0.39，P=0.014)和出生体质量(β=0.44，P=0.006)对其骨SOS的影响具显著性。结论新生适于胎龄儿血清瘦素及骨SOS均与胎龄、出生体质量呈正相关，瘦素对骨SOS有影响，但不是其直接影响因素。
目的：探討新生適于胎齡兒血清瘦素、骨聲波傳導速度(SOS)隨胎齡的變化，以及瘦素與新生兒骨SOS的關繫。方法共收集65例新生適于胎齡兒，根據胎齡分為早期早產兒組(胎齡31~34週，14例)，晚期早產兒組(胎齡34~37週，13例)，足月兒組(胎齡≥37週，38例)。所有研究對象均測量齣生體質量、身長、小腿長度，採用Ponderal指數(PI)估測新生兒營養狀態，採用weststrate公式(F%)估測新生兒體脂含量。生後7 d內採集靜脈血測定血清瘦素水平，同時採用超聲定量技術測量左側脛骨SOS。結果三組新生兒胎齡、齣生體質量、身長、小腿長度、F%、PI、血清瘦素與骨SOS的差異均有統計學意義(F=11.90~140.20，P均<0.01)；各變量均隨胎齡增大而增大(P均<0.05)。Pearson相關分析提示，除足月兒身長、PI外，三組新生兒的血清瘦素與其胎齡、齣生體質量、身長、PI、F%呈顯著正相關(r=0.36~0.78， P均<0.05)。三組新生兒骨SOS分彆與其瘦素、胎齡、齣生體質量及小腿長度呈顯著正相關(r=0.33~0.76，P均<0.05)。進一步多元線性逐步迴歸分析髮現，僅新生兒的胎齡(β=0.39，P=0.014)和齣生體質量(β=0.44，P=0.006)對其骨SOS的影響具顯著性。結論新生適于胎齡兒血清瘦素及骨SOS均與胎齡、齣生體質量呈正相關，瘦素對骨SOS有影響，但不是其直接影響因素。
목적：탐토신생괄우태령인혈청수소、골성파전도속도(SOS)수태령적변화，이급수소여신생인골SOS적관계。방법공수집65례신생괄우태령인，근거태령분위조기조산인조(태령31~34주，14례)，만기조산인조(태령34~37주，13례)，족월인조(태령≥37주，38례)。소유연구대상균측량출생체질량、신장、소퇴장도，채용Ponderal지수(PI)고측신생인영양상태，채용weststrate공식(F%)고측신생인체지함량。생후7 d내채집정맥혈측정혈청수소수평，동시채용초성정량기술측량좌측경골SOS。결과삼조신생인태령、출생체질량、신장、소퇴장도、F%、PI、혈청수소여골SOS적차이균유통계학의의(F=11.90~140.20，P균<0.01)；각변량균수태령증대이증대(P균<0.05)。Pearson상관분석제시，제족월인신장、PI외，삼조신생인적혈청수소여기태령、출생체질량、신장、PI、F%정현저정상관(r=0.36~0.78， P균<0.05)。삼조신생인골SOS분별여기수소、태령、출생체질량급소퇴장도정현저정상관(r=0.33~0.76，P균<0.05)。진일보다원선성축보회귀분석발현，부신생인적태령(β=0.39，P=0.014)화출생체질량(β=0.44，P=0.006)대기골SOS적영향구현저성。결론신생괄우태령인혈청수소급골SOS균여태령、출생체질량정정상관，수소대골SOS유영향，단불시기직접영향인소。
Objective To investigate the changes of serum leptin and bone speed of sound (SOS) with gestational age (GA) and relationship between leptin and bone SOS in appropriate-for-gestational-age (AGA) neonates. Methods A total of 65 AGA neonates were recruited and divided into three groups according to their gestational age:preterm infant (GA 31-34 w, 14 cases), late preterm infant (GA 34-37 w, 13 cases), and full-term infant (GA≥37 w, 38 cases). Anthropometric parameters, including birth weight, length, leg length, skin fold thickness were measured in all the subjects, and the neonatal nutritional status and body fat content were evaluated by Ponderal Index (PI) and Weststrate equation (F%) respectively. Serum leptin concentration and tibial SOS were measured within 7 days after birth. Results There were signiifcant differences in GA (F=140.199, P<0.001), birth weight (F=47.042, P<0.001), birth length (F=46.877, P<0.001), leg length (F=17.543, P<0.001), PI (F=11.898, P<0.001) and F%( F=21.955, P<0.001) among three groups. Serum leptin and tibial SOS were signiifcantly different among these groups ( F=49.724, 20.052 respectively, P<0.001), and both of them were positively correlated with gestational age and birth weight (P<0.01). In addition, leptin was positively correlated with tibial SOS, but the correlation disappeared after adjustment for GA and anthropometry. According to the multivariate forward stepwise regression analysis, tibial SOS was found to be signiifcantly positively associated with gestational age and birth weight in the three groups. Conclusions Both bone SOS and serum leptin are signiifcantly correlated with gestational age and birth weight in AGA neonates, and leptin is related with but not the independent direct predictor of bone SOS.
