临床儿科杂志
臨床兒科雜誌
림상인과잡지
2014年
9期
829-832
,共4页
缺氧缺血性脑病%脐血%脂联素%胰岛素样生长因子-1%新生儿
缺氧缺血性腦病%臍血%脂聯素%胰島素樣生長因子-1%新生兒
결양결혈성뇌병%제혈%지련소%이도소양생장인자-1%신생인
hypoxic ischemic encephalopathy%umbilical cord blood%adiponectin%insulin like growth factor-1%neonate
目的：探讨缺氧缺血性脑病(HIE)新生儿血清胰岛素样生长因子-1(IGF-1)、脂联素(APN)水平的变化。方法选择足月HIE新生儿52例(重度HIE组15例，中度HIE组20例，轻度HIE组17例)，测定脐血及生后3~5 d(HIE急性期)、10~14 d(HIE恢复期)的血清IGF-1、APN水平；另选同期出生的20例足月健康新生儿作为对照组。结果轻、中、重度HIE组及对照组四组间脐血及生后3~5 d时APN、IGF-1水平的差异有统计学意义(P均<0.01)，均随HIE程度加重而下降，两两比较差异有统计学意义(P均<0.05)；HIE恢复期新生儿APN、IGF-1水平显著增加，但APN水平中度HIE组和重度HIE组仍低于对照组，差异有统计学意义(P均<0.05)；重度HIE组IGF-1仍低于对照组，差异有统计学意义(P<0.05)；HIE患儿脐血、急性期血清IGF-1、APN水平呈显著正相关(r=0.53、0.61，P均<0.01)。结论 HIE患儿血清IGF-1、APN水平降低与HIE的病理生理过程密切相关，可作为病情程度的判断指标之一，对临床诊断及预后的判断具有指导意义。
目的：探討缺氧缺血性腦病(HIE)新生兒血清胰島素樣生長因子-1(IGF-1)、脂聯素(APN)水平的變化。方法選擇足月HIE新生兒52例(重度HIE組15例，中度HIE組20例，輕度HIE組17例)，測定臍血及生後3~5 d(HIE急性期)、10~14 d(HIE恢複期)的血清IGF-1、APN水平；另選同期齣生的20例足月健康新生兒作為對照組。結果輕、中、重度HIE組及對照組四組間臍血及生後3~5 d時APN、IGF-1水平的差異有統計學意義(P均<0.01)，均隨HIE程度加重而下降，兩兩比較差異有統計學意義(P均<0.05)；HIE恢複期新生兒APN、IGF-1水平顯著增加，但APN水平中度HIE組和重度HIE組仍低于對照組，差異有統計學意義(P均<0.05)；重度HIE組IGF-1仍低于對照組，差異有統計學意義(P<0.05)；HIE患兒臍血、急性期血清IGF-1、APN水平呈顯著正相關(r=0.53、0.61，P均<0.01)。結論 HIE患兒血清IGF-1、APN水平降低與HIE的病理生理過程密切相關，可作為病情程度的判斷指標之一，對臨床診斷及預後的判斷具有指導意義。
목적：탐토결양결혈성뇌병(HIE)신생인혈청이도소양생장인자-1(IGF-1)、지련소(APN)수평적변화。방법선택족월HIE신생인52례(중도HIE조15례，중도HIE조20례，경도HIE조17례)，측정제혈급생후3~5 d(HIE급성기)、10~14 d(HIE회복기)적혈청IGF-1、APN수평；령선동기출생적20례족월건강신생인작위대조조。결과경、중、중도HIE조급대조조사조간제혈급생후3~5 d시APN、IGF-1수평적차이유통계학의의(P균<0.01)，균수HIE정도가중이하강，량량비교차이유통계학의의(P균<0.05)；HIE회복기신생인APN、IGF-1수평현저증가，단APN수평중도HIE조화중도HIE조잉저우대조조，차이유통계학의의(P균<0.05)；중도HIE조IGF-1잉저우대조조，차이유통계학의의(P<0.05)；HIE환인제혈、급성기혈청IGF-1、APN수평정현저정상관(r=0.53、0.61，P균<0.01)。결론 HIE환인혈청IGF-1、APN수평강저여HIE적병리생리과정밀절상관，가작위병정정도적판단지표지일，대림상진단급예후적판단구유지도의의。
Objective To explore the changes and clinical value of serum insulin like growth factor-1 (IGF-1) and adiponectin in newborns with hypoxic ischemic encephalopathy (HIE). Methods Fifty-two HIE newborns were recruited in this study, including 15 severe, 20 moderate and 17 mild HIE newborns. Twenty healthy newborns were selected as controls. Serum levels of IGF-1 and adiponectin were detected 3-to-5 days (acute period) and 10-to-14 days (recovery period) after birth. Results Serum levels of IGF-1 and adiponectin in the acute period differed signiifcantly among groups of different severity (P<0.05). Serum levels of IGF-1 and adiponectin were decreased with the increase of HIE severity. The level of adiponectin in moderate and severe HIE was lower than that in mild HIE (P<0.05). In recovery period, the level of IGF-1 in severe HIE was lower than that in control (P<0.05). Serum levels of IGF-1 and adiponectin in the acute period was positivity correlated with those in umbilical cord blood of HIE newborns (r=0.531, r=0.611, P<0.01). Conclusions Decreased levels of IGF-l and adiponectin in HIE newborns are correlated with the pathological process of HIE, and can be regarded as indices for severity of HIE. IGF-l and adiponectin is of signiifcance in the clinical diagnosis and prognosis of HIE.
