临床儿科杂志
臨床兒科雜誌
림상인과잡지
2014年
9期
821-824
,共4页
脑室周围白质软化%白细胞介素-8%细胞间黏附分子-1%早产儿
腦室週圍白質軟化%白細胞介素-8%細胞間黏附分子-1%早產兒
뇌실주위백질연화%백세포개소-8%세포간점부분자-1%조산인
cerebral white matter damage%interleukin-8%intercellular adhesion molecule-1%premature infant
目的：探讨脑白质损伤(CWMD)早产儿早期血清白细胞介素-8(IL-8)和细胞间黏附分子(ICAM-1)变化及其与预后的关系。方法对2009年3月至2012年6月收治并获得随访的102例CWMD早产儿(CWMD组)和42例正常早产儿(对照组)，分别在生后48~72 h采集血清并检测IL-8和ICAM-1含量，12个月时采用Bayley婴幼儿发育量表对婴儿运动发育指数(PDI)及智能发育指数(MDI)进行评估，分析IL-8和ICAM-1水平与预后的相关性。结果轻、中、重CWMD组及对照组间血清IL-8和ICAM-1水平的差异有统计学意义(P<0.05)，且随着CWMD程度加重，IL-8和ICAM-1水平逐渐递增，差异有统计学意义(P均<0.05)。轻、中、重CWMD组的PDI、MDI的差异有统计学意义(P<0.05)，且随着CWMD程度加重，逐渐递减，差异也有统计学意义(P均<0.05)。CWMD组的血清IL-8和ICAM-1水平与MDI之间呈显著负相关(r=－0.64、－0.66，P均<0.05)，与PDI之间也呈显著负相关(r=－0.70、－0.71，P均<0.05)。结论 CWMD早产儿出生后血清IL-8和ICAM-1水平显著增高，并且与其12月龄时的MDI及PDI呈显著负相关。
目的：探討腦白質損傷(CWMD)早產兒早期血清白細胞介素-8(IL-8)和細胞間黏附分子(ICAM-1)變化及其與預後的關繫。方法對2009年3月至2012年6月收治併穫得隨訪的102例CWMD早產兒(CWMD組)和42例正常早產兒(對照組)，分彆在生後48~72 h採集血清併檢測IL-8和ICAM-1含量，12箇月時採用Bayley嬰幼兒髮育量錶對嬰兒運動髮育指數(PDI)及智能髮育指數(MDI)進行評估，分析IL-8和ICAM-1水平與預後的相關性。結果輕、中、重CWMD組及對照組間血清IL-8和ICAM-1水平的差異有統計學意義(P<0.05)，且隨著CWMD程度加重，IL-8和ICAM-1水平逐漸遞增，差異有統計學意義(P均<0.05)。輕、中、重CWMD組的PDI、MDI的差異有統計學意義(P<0.05)，且隨著CWMD程度加重，逐漸遞減，差異也有統計學意義(P均<0.05)。CWMD組的血清IL-8和ICAM-1水平與MDI之間呈顯著負相關(r=－0.64、－0.66，P均<0.05)，與PDI之間也呈顯著負相關(r=－0.70、－0.71，P均<0.05)。結論 CWMD早產兒齣生後血清IL-8和ICAM-1水平顯著增高，併且與其12月齡時的MDI及PDI呈顯著負相關。
목적：탐토뇌백질손상(CWMD)조산인조기혈청백세포개소-8(IL-8)화세포간점부분자(ICAM-1)변화급기여예후적관계。방법대2009년3월지2012년6월수치병획득수방적102례CWMD조산인(CWMD조)화42례정상조산인(대조조)，분별재생후48~72 h채집혈청병검측IL-8화ICAM-1함량，12개월시채용Bayley영유인발육량표대영인운동발육지수(PDI)급지능발육지수(MDI)진행평고，분석IL-8화ICAM-1수평여예후적상관성。결과경、중、중CWMD조급대조조간혈청IL-8화ICAM-1수평적차이유통계학의의(P<0.05)，차수착CWMD정도가중，IL-8화ICAM-1수평축점체증，차이유통계학의의(P균<0.05)。경、중、중CWMD조적PDI、MDI적차이유통계학의의(P<0.05)，차수착CWMD정도가중，축점체감，차이야유통계학의의(P균<0.05)。CWMD조적혈청IL-8화ICAM-1수평여MDI지간정현저부상관(r=－0.64、－0.66，P균<0.05)，여PDI지간야정현저부상관(r=－0.70、－0.71，P균<0.05)。결론 CWMD조산인출생후혈청IL-8화ICAM-1수평현저증고，병차여기12월령시적MDI급PDI정현저부상관。
Objective To explore the IL-8 and ICAM-1 in premature infants with cerebral white matter damage (CWMD) and their correlations with prognosis. Methods One hundred and two cases of CWMD were selected from March 2009 to June 2012 as experimental group and 42 cases of normal preterm children were selected as control group. Serum IL-8 and ICAM-1 levels were measured during 48-72 h after birth. Motor development index (psychomotor developmental index, PDI) and mental development index (mental development index, MDI) were evaluated by Bayley scale. The correlations of IL-8 and ICAM-1 levels with prognosis were analyzed. Results Serum IL-8 and ICAM-1 levels in the experimental group were signiifcantly higher than those in the control group (P<0.05). MDI and PDI scores in the experimental group were signiifcantly lower than those in the control group (P<0.05). There were negative correlations of serum IL-8 and ICAM-1 levels with MDI (r=-0.64, P<0.05;r=-0.66, P<0.05)+and PDI (r=-0.70, P<0.05;r=-0.71, P<0.05). Conclusions Serum IL-8 and ICAM-1 levels in infants with CWMD are signiifcantly increased, and are negatively correlated with MDI and PDI scores.
