国际中医中药杂志
國際中醫中藥雜誌
국제중의중약잡지
INTERNATIONAL JOURNAL OF TRIDITIONAL CHINESE MEDICINE
2013年
9期
789-791
,共3页
人参皂苷Compound K注射液%主动全身过敏试验%被动皮肤过敏试验
人參皂苷Compound K註射液%主動全身過敏試驗%被動皮膚過敏試驗
인삼조감Compound K주사액%주동전신과민시험%피동피부과민시험
Ginenoside compound K injection%Active systemic anaphylaxis%Passive cutaneous anaphylaxis
目的 评价人参皂苷Compound K注射液的免疫毒性.方法 采用主动全身过敏试验、被动皮肤过敏试验对人参皂苷Compound K注射液的免疫毒性进行评价.结果 主动全身过敏试验中,阳性对照过敏反应呈极强阳性,人参皂苷Compound K注射液的高、低剂量组均未见过敏反应,各组豚鼠的体重变化未见明显差异.被动皮肤过敏试验中,阳性对照组各动物均出现蓝斑,且直径＞5mm,左侧蓝斑直径(10.1±3.34)mm,右侧蓝斑直径(7.57±1.94)mm,血清IgE含量明显增高(P＜0.01),人参皂苷Compound K注射液的高、低剂量组均未出现直径＞5 mm的蓝斑,血清IgE含量未见明显改变.结论 人参皂苷Compound K注射液在该实验条件下未见免疫毒性.
目的 評價人參皂苷Compound K註射液的免疫毒性.方法 採用主動全身過敏試驗、被動皮膚過敏試驗對人參皂苷Compound K註射液的免疫毒性進行評價.結果 主動全身過敏試驗中,暘性對照過敏反應呈極彊暘性,人參皂苷Compound K註射液的高、低劑量組均未見過敏反應,各組豚鼠的體重變化未見明顯差異.被動皮膚過敏試驗中,暘性對照組各動物均齣現藍斑,且直徑＞5mm,左側藍斑直徑(10.1±3.34)mm,右側藍斑直徑(7.57±1.94)mm,血清IgE含量明顯增高(P＜0.01),人參皂苷Compound K註射液的高、低劑量組均未齣現直徑＞5 mm的藍斑,血清IgE含量未見明顯改變.結論 人參皂苷Compound K註射液在該實驗條件下未見免疫毒性.
목적 평개인삼조감Compound K주사액적면역독성.방법 채용주동전신과민시험、피동피부과민시험대인삼조감Compound K주사액적면역독성진행평개.결과 주동전신과민시험중,양성대조과민반응정겁강양성,인삼조감Compound K주사액적고、저제량조균미견과민반응,각조돈서적체중변화미견명현차이.피동피부과민시험중,양성대조조각동물균출현람반,차직경＞5mm,좌측람반직경(10.1±3.34)mm,우측람반직경(7.57±1.94)mm,혈청IgE함량명현증고(P＜0.01),인삼조감Compound K주사액적고、저제량조균미출현직경＞5 mm적람반,혈청IgE함량미견명현개변.결론 인삼조감Compound K주사액재해실험조건하미견면역독성.
Objective Evaluate the immunotoxicity of Ginenoside Compound K Injection.Methods Active Systemic Anaphylaxis (ASA)tests and Passive Cutaneous Anaphylaxis (PCA)tests were used to evaluate Ginenoside Compound K Injection.Results In the ASA tests,positive control group showed pole-strength anapbylaxis,both the high-dose group and the low-dose group of Ginenoside Compound K Injection didn't produce allergic reaction and the body weights of all groups showed no significant differences.In the PCA tests,all rats of positive control group caused blue spots with their diameters bigger than 5 mm (diameters on the left side of blue spots was (10.1± 3.34) mm and diameters on the right side of blue spots was(7.57± 1.94)mm.Serum IgE was significantly increased.While both high dose and low dose of Ginenoside Compound K Injection group didn't show blue spots with their diameters greater than 5 mm and their IgE levels showed no significant differences compared with negative control group.Conclusion Ginenoside Compound K Injection showed no immunotoxicity under these experimental conditions.
