国际外科学杂志
國際外科學雜誌
국제외과학잡지
INTERNATIONAL JOURNAL OF SURGERY
2013年
3期
164-166,封3
,共4页
淋巴瘤,B细胞%胃肿瘤%癌%细胞凋亡
淋巴瘤,B細胞%胃腫瘤%癌%細胞凋亡
림파류,B세포%위종류%암%세포조망
Lymphoma,B-cell%Stomach neoplasms%Carcinoma%Apoptosis
目的 研究B细胞淋巴瘤／白血病-2基因(Bcl-2)在胃癌中的表达,以探讨其与胃癌临床生物学行为和预后的关系.方法 应用免疫组织化学SP法分别检测Bcl-2在42例胃癌患者的胃癌及切缘上皮组织中的表达.结果 Bcl-2在胃癌和胃切缘上皮组织中的阳性表达率分别为69.05％和21.43％,两者差异有统计学意义(P＜0.05)；Bcl-2表达水平与胃癌患者的年龄、性别和浸润深度无关(P＞0.05),而与肿瘤分化程度、TNM分期、淋巴结转移有关(P＜0.05).结论 胃癌中Bcl-2表达可能是胃癌侵袭、转移、演进和预后的生物学标志之一.
目的 研究B細胞淋巴瘤／白血病-2基因(Bcl-2)在胃癌中的錶達,以探討其與胃癌臨床生物學行為和預後的關繫.方法 應用免疫組織化學SP法分彆檢測Bcl-2在42例胃癌患者的胃癌及切緣上皮組織中的錶達.結果 Bcl-2在胃癌和胃切緣上皮組織中的暘性錶達率分彆為69.05％和21.43％,兩者差異有統計學意義(P＜0.05)；Bcl-2錶達水平與胃癌患者的年齡、性彆和浸潤深度無關(P＞0.05),而與腫瘤分化程度、TNM分期、淋巴結轉移有關(P＜0.05).結論 胃癌中Bcl-2錶達可能是胃癌侵襲、轉移、縯進和預後的生物學標誌之一.
목적 연구B세포림파류／백혈병-2기인(Bcl-2)재위암중적표체,이탐토기여위암림상생물학행위화예후적관계.방법 응용면역조직화학SP법분별검측Bcl-2재42례위암환자적위암급절연상피조직중적표체.결과 Bcl-2재위암화위절연상피조직중적양성표체솔분별위69.05％화21.43％,량자차이유통계학의의(P＜0.05)；Bcl-2표체수평여위암환자적년령、성별화침윤심도무관(P＞0.05),이여종류분화정도、TNM분기、림파결전이유관(P＜0.05).결론 위암중Bcl-2표체가능시위암침습、전이、연진화예후적생물학표지지일.
Objective To investigate the expression of B-cell lymphoma/leukemia-2 gene (Bcl-2) in the gastric carcinoma,and the relationship between Bcl-2 and clinical biological behaviour and prognosis.Methods To use SP immunohistochemistry to detect respectively the expression level of Bcl-2 in the gastric carcinoma and incisal margin epithelial tissue of 42 gastric carcinoma patients.Results The positive expression rates of Bcl-2 in the gastric carcinoma and incisal margin epithelial tissue were 69.05％ and 21.43％.It had statistical significance (P ＜0.05) ; the expression of Bcl-2 in gastric carcinoma had not significantly correlation repectively with patient' s age,gender and invasive depth (P ＞ 0.05),but had significantly correlation with differentiation,TNM stage and lymph node metastasis of the tumor (P ＜ 0.05).Conclusion The expression level of Bcl-2 in gastric carcinoma may be one of biology indexes of the inwsion,migration,advancement and prognosis of the gastric carcinoma.
