放射学实践
放射學實踐
방사학실천
RADIOLOGIC PRACTICE
2014年
9期
1064-1066
,共3页
胰腺肿瘤%胰腺疾病%磁共振波谱成像%磁共振成像
胰腺腫瘤%胰腺疾病%磁共振波譜成像%磁共振成像
이선종류%이선질병%자공진파보성상%자공진성상
Pancreatic neoplasms%Pancreatic diseases%Magnetic resonance spectroscopy%Magnetic resonance ima-ging
_目的：探讨磁共振波谱（MRS）对胰腺癌的诊断价值。方法：应用单体素点分辨波谱（PRESS）序列，采集53例非胰腺癌受检者（包括26例正常胰腺，16例急性胰腺炎，11例慢性胰腺炎）及22例胰腺癌患者的胰腺质子磁共振波谱（1 H-MRS）图像。通过分析非癌组与癌组胰腺波谱中代谢物的表现，比较两组的代谢物峰显示率，计算每组胰腺波谱中胆固醇和不饱和脂肪酸的混合峰（Chol＋Unsat）与脂肪峰（Lip）峰高的比值（Chol＋Unsat/Lip），在胰腺癌与非胰腺癌的比值之间进行受试者工作特征（ROC）曲线分析。结果：胰腺1 H-MRS 显示的主要代谢物峰有 Lip 峰、Chol＋Unsat 峰和胆碱（Cho）峰。胰腺癌组与非胰腺癌组的 Chol＋Unsat/Lip 比值分别为0．181±0．059和0．328±0．111，两组比值差异有统计学意义（r＝2．913，P＝0．008）。经计算得出 ROC 曲线下面积为0．857（P＝0．000）。当 Chol＋Unsat/Lip 比值临界值取0．286时，1 H-MRS 鉴别诊断胰腺癌与非胰腺癌的敏感度为68．2％，特异度为100％。结论：胰腺1 H-MRS 中 Chol＋Un-sat/Lip 比值升高对诊断胰腺癌有一定价值。
_目的：探討磁共振波譜（MRS）對胰腺癌的診斷價值。方法：應用單體素點分辨波譜（PRESS）序列，採集53例非胰腺癌受檢者（包括26例正常胰腺，16例急性胰腺炎，11例慢性胰腺炎）及22例胰腺癌患者的胰腺質子磁共振波譜（1 H-MRS）圖像。通過分析非癌組與癌組胰腺波譜中代謝物的錶現，比較兩組的代謝物峰顯示率，計算每組胰腺波譜中膽固醇和不飽和脂肪痠的混閤峰（Chol＋Unsat）與脂肪峰（Lip）峰高的比值（Chol＋Unsat/Lip），在胰腺癌與非胰腺癌的比值之間進行受試者工作特徵（ROC）麯線分析。結果：胰腺1 H-MRS 顯示的主要代謝物峰有 Lip 峰、Chol＋Unsat 峰和膽堿（Cho）峰。胰腺癌組與非胰腺癌組的 Chol＋Unsat/Lip 比值分彆為0．181±0．059和0．328±0．111，兩組比值差異有統計學意義（r＝2．913，P＝0．008）。經計算得齣 ROC 麯線下麵積為0．857（P＝0．000）。噹 Chol＋Unsat/Lip 比值臨界值取0．286時，1 H-MRS 鑒彆診斷胰腺癌與非胰腺癌的敏感度為68．2％，特異度為100％。結論：胰腺1 H-MRS 中 Chol＋Un-sat/Lip 比值升高對診斷胰腺癌有一定價值。
_목적：탐토자공진파보（MRS）대이선암적진단개치。방법：응용단체소점분변파보（PRESS）서렬，채집53례비이선암수검자（포괄26례정상이선，16례급성이선염，11례만성이선염）급22례이선암환자적이선질자자공진파보（1 H-MRS）도상。통과분석비암조여암조이선파보중대사물적표현，비교량조적대사물봉현시솔，계산매조이선파보중담고순화불포화지방산적혼합봉（Chol＋Unsat）여지방봉（Lip）봉고적비치（Chol＋Unsat/Lip），재이선암여비이선암적비치지간진행수시자공작특정（ROC）곡선분석。결과：이선1 H-MRS 현시적주요대사물봉유 Lip 봉、Chol＋Unsat 봉화담감（Cho）봉。이선암조여비이선암조적 Chol＋Unsat/Lip 비치분별위0．181±0．059화0．328±0．111，량조비치차이유통계학의의（r＝2．913，P＝0．008）。경계산득출 ROC 곡선하면적위0．857（P＝0．000）。당 Chol＋Unsat/Lip 비치림계치취0．286시，1 H-MRS 감별진단이선암여비이선암적민감도위68．2％，특이도위100％。결론：이선1 H-MRS 중 Chol＋Un-sat/Lip 비치승고대진단이선암유일정개치。
To study the value of 3.0T 1 H-MRS in the diagnosis of pancreatic cancer.Methods:Spectrosco-pies of pancreas in 75 subjects were acquired with single voxel PRESS sequence on a 3.0T MR scanner.The subjects includ-ed normal pancreas (n=26),acute pancreatitis (n=16),chronic pancreatitis (n=11)and pancreatic cancer (n=22).The spectral appearances were analyzed,and metabolites visibility rates between pancreatic cancer and non-cancer group were compared.The ratio of cholesterol and the olefinic region of fatty acids (Chol +Unsat)peak height to lipid (Lip)peak height (Chol+Unsat/Lip)was calculated in each 1 H-MRS,and a ROC analysis was performed between the ratios of two groups.Results:There were three major resonance peaks in the spectra:Lip,Chol+Unsat,and choline.The mean value of Chol+Unsat/Lip in 1 H-MRS was 0.181±0.059 for non-cancer group,and 0.328±0.111 for pancreatic cancer group.Sta-tistically significant difference was found in the values of Chol+Unsat/Lip ratios between cancer and non-cancer group (r=2.913,P=0.008).The area under the ROC curve was 0.857 (P=0.000).With ROC cut point setting to 0.286,the diag-nostic sensitivity and specificity for pancreatic cancer were 68.2% and 85.9%,respectively.Conclusion:1 H-MRS of pancre-atic cancer has a higher ratio of Chol+Unsat/Lip,and this may be useful in differentiating pancreatic cancer from other pan-creatic diseases.
