CAJ | 학술논문

_目的：探讨18 F-FDG 符合线路 SPECT/CT 显像对肺部病变的诊断价值。方法：回顾性分析经病理或随访证实的144例肺部病变患者的18 F-FDG 符合线路 SPECT/CT 检查图像，采用半定量法测量肺部病灶放射性计数（T）与胸壁软组织放射性计数（NT），并计算其放射性摄取比值 R（T/NT），应用受试者工作特征（ROC）曲线确定肺部良恶性病变的最佳临界值 R（cutoff），即 R≥R（cutoff）诊断为恶性病变，R＜R（cutoff）诊断为良性病变。结果：R（cutoff）取3．58，即病灶R≥3．58作为恶性的判定标准，诊断敏感度、特异度、准确率、阳性预测值和阴性预测值分别为89．5％、89．7％、89．6％、95．9％和76．1％，且与病理诊断的一致性良好（Kappa＝0．750，P＜0．05）。结论：18 F-FDG 符合线路 SPECT/CT 显像对肺部病变的诊断、鉴别诊断及预后评估具有重要的临床应用价值。
_목적：탐토18 F-FDG 부합선로 SPECT/CT 현상대폐부병변적진단개치。방법：회고성분석경병리혹수방증실적144례폐부병변환자적18 F-FDG 부합선로 SPECT/CT 검사도상，채용반정량법측량폐부병조방사성계수（T）여흉벽연조직방사성계수（NT），병계산기방사성섭취비치 R（T/NT），응용수시자공작특정（ROC）곡선학정폐부량악성병변적최가림계치 R（cutoff），즉 R≥R（cutoff）진단위악성병변，R＜R（cutoff）진단위량성병변。결과：R（cutoff）취3．58，즉병조R≥3．58작위악성적판정표준，진단민감도、특이도、준학솔、양성예측치화음성예측치분별위89．5％、89．7％、89．6％、95．9％화76．1％，차여병리진단적일치성량호（Kappa＝0．750，P＜0．05）。결론：18 F-FDG 부합선로 SPECT/CT 현상대폐부병변적진단、감별진단급예후평고구유중요적림상응용개치。
To explore the diagnostic value of 18 F-FDG coincidence SPECT/CT imaging in diagnostic of lung lesions.Methods:Images of 144 patients with lung diseases confirmed by pathology or follow-ups were analyzed retro-spectively.The maximum radioactivity count of the lung lesions (T)and normal chest wall soft tissues (NT)were meas-ured by the two experienced nuclear medicine doctors and the ratios of R (T/NT)were calculated.The optimal threshold of R (cutoff)was identified by the receiver operating characteristic (ROC)curve analysis.With optimal threshold,R≥R (cut-off)was diagnosed as malignant lesions,R<R (cutoff)was diagnosed as benign lesions,and the data were analyzed statisti-cally.Results:The optimal threshold value (R-cutoff)was 3.58.When R (cutoff)≥3.58 the tumors were diagnosed as ma-lignant lesions.The sensitivity,specificity,accuracy,positive predictive value and negative predictive value were respective-ly:89.5%,89.7%,89.6%,95.9% and 76.1%,showing adequate consistency as compared with pathologic diagnosis (Kap-pa=0.750,P<0.05).Conclusion:18 F-FDG-Coincidence SPECT/CT imaging is clinically valuable for diagnosis,differential diagnosis and prognosis in lung diseases.