中国基层医药
中國基層醫藥
중국기층의약
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
2012年
21期
3222-3223
,共2页
肝炎,乙型,慢性%肝硬化%胶原Ⅳ型%透明质酸%层粘连蛋白%胶原Ⅲ型
肝炎,乙型,慢性%肝硬化%膠原Ⅳ型%透明質痠%層粘連蛋白%膠原Ⅲ型
간염,을형,만성%간경화%효원Ⅳ형%투명질산%층점련단백%효원Ⅲ형
Hepatitis B,Chronic%Liver cirrhosis%Collagen type Ⅳ%Hyaluronic acid%Laminin%Collagen type Ⅲ
目的 探讨慢性病毒性乙型肝炎(乙肝)患者血清肝纤维化指标水平与临床的关系.方法 应用放射免疫法及化学发光法检测146例慢性病毒性乙型肝炎患者及40例健康人(对照组)血清肝纤维化指标血清透明质酸(HA)、Ⅳ型胶原(Ⅳ-C)、层粘连蛋白(LN)及Ⅲ型前胶原(PCⅢ)水平,并就上述指标与临床肝功能指标关系进行分析.结果 慢性乙肝患者血清HA、Ⅳ-C、LN、PCⅢ水平均不同程度高于对照组(P＜0.05或P＜0.01),在不同病程之间差异有统计学意义(P＜0.05或P＜0.01)；慢性乙肝患者血清Ⅳ-C、PCⅢ水平与血浆PT呈正相关,HA、Ⅳ-C、LN水平与Alb呈负相关,HA水平与TBil呈正相关,PCⅢ水平与ALT呈正相关,LN水平与CHE呈负相关.结论 检测慢性病毒性乙型肝炎患者血清HA、Ⅳ-C、LN、PCⅢ水平,可反映肝纤维化进展情况和肝功能损害程度.
目的 探討慢性病毒性乙型肝炎(乙肝)患者血清肝纖維化指標水平與臨床的關繫.方法 應用放射免疫法及化學髮光法檢測146例慢性病毒性乙型肝炎患者及40例健康人(對照組)血清肝纖維化指標血清透明質痠(HA)、Ⅳ型膠原(Ⅳ-C)、層粘連蛋白(LN)及Ⅲ型前膠原(PCⅢ)水平,併就上述指標與臨床肝功能指標關繫進行分析.結果 慢性乙肝患者血清HA、Ⅳ-C、LN、PCⅢ水平均不同程度高于對照組(P＜0.05或P＜0.01),在不同病程之間差異有統計學意義(P＜0.05或P＜0.01)；慢性乙肝患者血清Ⅳ-C、PCⅢ水平與血漿PT呈正相關,HA、Ⅳ-C、LN水平與Alb呈負相關,HA水平與TBil呈正相關,PCⅢ水平與ALT呈正相關,LN水平與CHE呈負相關.結論 檢測慢性病毒性乙型肝炎患者血清HA、Ⅳ-C、LN、PCⅢ水平,可反映肝纖維化進展情況和肝功能損害程度.
목적 탐토만성병독성을형간염(을간)환자혈청간섬유화지표수평여림상적관계.방법 응용방사면역법급화학발광법검측146례만성병독성을형간염환자급40례건강인(대조조)혈청간섬유화지표혈청투명질산(HA)、Ⅳ형효원(Ⅳ-C)、층점련단백(LN)급Ⅲ형전효원(PCⅢ)수평,병취상술지표여림상간공능지표관계진행분석.결과 만성을간환자혈청HA、Ⅳ-C、LN、PCⅢ수평균불동정도고우대조조(P＜0.05혹P＜0.01),재불동병정지간차이유통계학의의(P＜0.05혹P＜0.01)；만성을간환자혈청Ⅳ-C、PCⅢ수평여혈장PT정정상관,HA、Ⅳ-C、LN수평여Alb정부상관,HA수평여TBil정정상관,PCⅢ수평여ALT정정상관,LN수평여CHE정부상관.결론 검측만성병독성을형간염환자혈청HA、Ⅳ-C、LN、PCⅢ수평,가반영간섬유화진전정황화간공능손해정도.
Objective To study the relationship between serum fibrosis parameters levels and chronic viral hepatitis B patients.Methods Radioimmunoassay and chemiluminescence were used to test the levels of hyaluronic acid(HA),collagen type Ⅳ(Ⅳ-C),laminin(LN) and procollagen type Ⅲ(PC Ⅲ) in 146 cases of chronic hepatitis B and 40 of normal controls,and the relationship with clinical parameters of liver function were analyzed.Results The levels of HA,Ⅳ-C,LN,PC Ⅲ in chronic hepatitis B patients were higher than those of normal control group (P ＜0.05 or P ＜ 0.01),there were statistical differen in different course of disease (P ＜ 0.05 or P ＜ 0.01) ; The levels of serum Ⅳ-C and PCⅢ had positive correlation with plasma PT,the same to HA with TBil and PCⅢ with ALT;The levels of HA,Ⅳ-C and LN had negative correlation with Alb,the same to LN with CHE.Conclusion The levels of HA,Ⅳ-C,LN and PC Ⅲ in chronic hepatitis B patients may reflect the situations of hepatic fibrosis and the degrees of liver function damage.
