中华神经外科杂志
中華神經外科雜誌
중화신경외과잡지
Chinese Journal of Neurosurgery
2012年
11期
1137-1140
,共4页
田永吉%李德岭%甲戈%张玉琪%马振宇
田永吉%李德嶺%甲戈%張玉琪%馬振宇
전영길%리덕령%갑과%장옥기%마진우
视路胶质瘤%儿童%放疗%无进展生存
視路膠質瘤%兒童%放療%無進展生存
시로효질류%인동%방료%무진전생존
Optic pathway gliomas%Pediatric%Radiotherapy%Progression-free survival
目的 探讨我国儿童视路胶质瘤的临床特征、治疗方法及预后.方法 回顾性分析2003年4月至2011年1月在北京天坛医院小儿神经外科专业病房收治的53例视路胶质瘤患者临床资料,通过随访,分析无进展生存的影响因素.结果 本组患者平均年龄7.6岁(10个月~15岁),以DodgeⅡ型为主,均接受肿瘤部分切除术,随访到的41例患者中,其中30例稳定,11例进展,无进展生存期平均为26个月(3-64个月),术后是否接受放疗差异具有统计学意义(P<0.01),合并神经纤维瘤病1型(NF-1)的2例,占4%.结论 我国儿童视路胶质瘤与国外报道的临床特征存在一定差别,肿瘤部分切除术可以有效降低手术并发症,结合术后放射治疗可有效控制肿瘤,获得较好的 治疗效果.
目的 探討我國兒童視路膠質瘤的臨床特徵、治療方法及預後.方法 迴顧性分析2003年4月至2011年1月在北京天罈醫院小兒神經外科專業病房收治的53例視路膠質瘤患者臨床資料,通過隨訪,分析無進展生存的影響因素.結果 本組患者平均年齡7.6歲(10箇月~15歲),以DodgeⅡ型為主,均接受腫瘤部分切除術,隨訪到的41例患者中,其中30例穩定,11例進展,無進展生存期平均為26箇月(3-64箇月),術後是否接受放療差異具有統計學意義(P<0.01),閤併神經纖維瘤病1型(NF-1)的2例,佔4%.結論 我國兒童視路膠質瘤與國外報道的臨床特徵存在一定差彆,腫瘤部分切除術可以有效降低手術併髮癥,結閤術後放射治療可有效控製腫瘤,穫得較好的 治療效果.
목적 탐토아국인동시로효질류적림상특정、치료방법급예후.방법 회고성분석2003년4월지2011년1월재북경천단의원소인신경외과전업병방수치적53례시로효질류환자림상자료,통과수방,분석무진전생존적영향인소.결과 본조환자평균년령7.6세(10개월~15세),이DodgeⅡ형위주,균접수종류부분절제술,수방도적41례환자중,기중30례은정,11례진전,무진전생존기평균위26개월(3-64개월),술후시부접수방료차이구유통계학의의(P<0.01),합병신경섬유류병1형(NF-1)적2례,점4%.결론 아국인동시로효질류여국외보도적림상특정존재일정차별,종류부분절제술가이유효강저수술병발증,결합술후방사치료가유효공제종류,획득교호적 치료효과.
Objective To study the clinical characteristics of optic pathway gliomas (OPG) in in China and evaluate the treatment of microsurgical management followed by postoperative radiotherapy for these patients.Methods All OPG cases treated in Beijing Tiantan Hospital from April 2003 to January 2011 were retrospectively reviewed.All patients' clinical data were collected and analyzed.Results The mean age of 53 patients at presentation was 7.6 years (range 10 months-15 years) old.There were only 2cases of NF1 in the OPG patients.Based on the Dodge classification,type Ⅰ covered 6% (3 cases),type Ⅱ68% (36 cases) and type Ⅲ 26% (14 cases).All tumors were partial resected (< 50%) and postoperative pathology showed fibrillary astrocytes in 27 cases (51%) and pilocytic astrocytomas in 24(45%).There were one oligodendrboglioma and one ganglioglioma.41 patients (77%) were continually followed-up from 3 months to 8 years (31 months in average).The symptoms were worsen in 11 cases and stable in 30 cases.The mean progression-free survival (PFS) was 26 months (ranged from 3 to 64months).The patients received radiotherapy had a significant better PFS than those without radiotherapy (P < 0.01).The radiotherapy side-effects occurred only in 1 patient with hypothyroidism.Conclusions Partial resection of tumor followed by radiotherapy is efficient to control OPG with less complications.There are less NF1 in Han nationality in China compared with OPG patients in existing literatures from other countries.