CAJ | 학술논문

目的探讨急性心肌梗死（AMI）患者血浆Adropin水平与心功能的关系。方法选择108例AMI患者（AMI组）及60例健康对照者（对照组）。使用Kil ip心功能分级标准评价AMI患者的心功能，采用超声心动图测量AMI患者的左心室射血分数（LVEF），使用ELISA法测定两组的血浆Adropin水平。结果 AMI组患者血浆Adropin水平（11.46±1.59）ng/ml，较对照组（6.28±0.72）ng/ml明显增高（P＜0.01）。血浆Adropin水平随Killip心功能分级的增加而增高（r=0.318，P＜0.05），而与LVEF值呈负相关（r=-0.225，P＜0.01）。结论血浆Adropin水平越高的AMI患者心功能越差，Adropin是预测AMI患者心功能的一个潜在的生物学标记物。
목적탐토급성심기경사（AMI）환자혈장Adropin수평여심공능적관계。방법선택108례AMI환자（AMI조）급60례건강대조자（대조조）。사용Kil ip심공능분급표준평개AMI환자적심공능，채용초성심동도측량AMI환자적좌심실사혈분수（LVEF），사용ELISA법측정량조적혈장Adropin수평。결과 AMI조환자혈장Adropin수평（11.46±1.59）ng/ml，교대조조（6.28±0.72）ng/ml명현증고（P＜0.01）。혈장Adropin수평수Killip심공능분급적증가이증고（r=0.318，P＜0.05），이여LVEF치정부상관（r=-0.225，P＜0.01）。결론혈장Adropin수평월고적AMI환자심공능월차，Adropin시예측AMI환자심공능적일개잠재적생물학표기물。
Objective To assess the correlation between plasma adropin levels and cardiac function in patients with acute myocardial infarction (AMI). Methods 108 patients with AMI and 60 healthy people were enrol ed. Left ventricular ejection fraction(LVEF) was assessed by echocardiography. Plasma adropin levels were measured by enzyme- linked im-munosorbent assay(ELISA). Cardiac function was determined according to Kil ip classification. Results Plasma adropin levels were significantly higher in AMI group than in control group [(11.46±1.59)ng/ml vs (6.28±0.72)ng/ml, P<0.01]. Plasma adropin level increased with the increment of Kil ip classification (r=0.318, P<0.01) and was negatively correlated with LVEF(r=- 0.225, P<0.01). Conclusion Patients with high adropin may have deteriorated cardiac function after AMI. Adropin may be a potential biomarker reflecting cardiac function in patients with AMI.