CAJ | 학술논문

目的：考察对乙酰氨基酚合成工艺的条件，反应条件涉及温度、物料比、反应时间、及反应溶剂等各条件对反应收率的影响。方法：通过正交设计寻找最佳工艺，运用熔点测定仪、元素分析、IR等手段进行确认。结果：棉酚与磺胺衍生物合成的最佳工艺为反应温度45℃，反应时间为1h ，反应溶剂为无水乙醇，物料比为1：2．5。结论：生成的衍生物有较强的脂溶性，在优化工艺下进行反应产量较高，为乙酰氨基酚衍生物合成提供了较好的方法。
목적：고찰대을선안기분합성공예적조건，반응조건섭급온도、물료비、반응시간、급반응용제등각조건대반응수솔적영향。방법：통과정교설계심조최가공예，운용용점측정의、원소분석、IR등수단진행학인。결과：면분여광알연생물합성적최가공예위반응온도45℃，반응시간위1h ，반응용제위무수을순，물료비위1：2．5。결론：생성적연생물유교강적지용성，재우화공예하진행반응산량교고，위을선안기분연생물합성제공료교호적방법。
Objective:In this paper ,a method of studying paracetamol synthesis technology of conditions , reaction conditions concerned with reaction temperation ,ratio of reactants ,reaction time and sort of solvent . Methods:by orthogonal experimental design search for best process ,use melting point apparatus ,UV ,IR , determination measure whether have the new material .By TLC monitor the extent of reactions .Results:paracetamol synthesis technology of best condition is reaction temperation 45℃ ,reaction time 1h ,sort of solvent is anhydrous ,and alcohol ratio of reactants 1 :2 .5 .Conclusion:these derivatives have strong fat -soluble ,by orthogonal experimental design search for best process have high yield ,and provide a good meth-od of studying p-acetaminophenol synthesis .