南通大学学报（医学版）
南通大學學報（醫學版）
남통대학학보（의학판）
JOURNAL OF NANTONG UNIVERSITY(MEDICAL SCIENCES)
2013年
6期
498-499,500
,共3页
牛黄降压片%冰片%樟脑%气相色谱法
牛黃降壓片%冰片%樟腦%氣相色譜法
우황강압편%빙편%장뇌%기상색보법
Niuhuang Jiangya tablet%borneol%camphor%gas chromatography
目的：建立牛黄降压片中冰片含量及樟脑残留量的测定方法。方法：气相色谱法，采用色谱柱19091N-213和INNOWAX石英毛细管色谱柱(30 m×0.32 mm×0.5μm)，柱温130℃，FID为检测器，无水乙醇为提取溶剂。结果：冰片质量浓度在0.0975～3.8984 mg/mL 范围内与峰面积呈良好的线性关系(r=0.9999)，平均加样回收率(n=6)为101.0%，相对标准偏差(relative standard deviation，RSD)为0.71%；樟脑浓度在1.041～20.82μg/μL范围内与峰面积呈现良好的线性关系(r=0.9995)，平均加样回收率(n=6)为100.4%， RSD为1.4%。结论：气相色谱法简便、灵敏、专属性强，适用于牛黄降压片的质量控制。
目的：建立牛黃降壓片中冰片含量及樟腦殘留量的測定方法。方法：氣相色譜法，採用色譜柱19091N-213和INNOWAX石英毛細管色譜柱(30 m×0.32 mm×0.5μm)，柱溫130℃，FID為檢測器，無水乙醇為提取溶劑。結果：冰片質量濃度在0.0975～3.8984 mg/mL 範圍內與峰麵積呈良好的線性關繫(r=0.9999)，平均加樣迴收率(n=6)為101.0%，相對標準偏差(relative standard deviation，RSD)為0.71%；樟腦濃度在1.041～20.82μg/μL範圍內與峰麵積呈現良好的線性關繫(r=0.9995)，平均加樣迴收率(n=6)為100.4%， RSD為1.4%。結論：氣相色譜法簡便、靈敏、專屬性彊，適用于牛黃降壓片的質量控製。
목적：건립우황강압편중빙편함량급장뇌잔류량적측정방법。방법：기상색보법，채용색보주19091N-213화INNOWAX석영모세관색보주(30 m×0.32 mm×0.5μm)，주온130℃，FID위검측기，무수을순위제취용제。결과：빙편질량농도재0.0975～3.8984 mg/mL 범위내여봉면적정량호적선성관계(r=0.9999)，평균가양회수솔(n=6)위101.0%，상대표준편차(relative standard deviation，RSD)위0.71%；장뇌농도재1.041～20.82μg/μL범위내여봉면적정현량호적선성관계(r=0.9995)，평균가양회수솔(n=6)위100.4%， RSD위1.4%。결론：기상색보법간편、령민、전속성강，괄용우우황강압편적질량공제。
Objectiv e: To establish the determination method of borneol content and camphor residue in Niuhuang Jiangya tablet. Methods: Gas chromatography(GC),The samples were separated on a quartz capillary column of 19091N-213 IN-NOWAX (30 m×0.32 mm×0.5μm);column temperature was 130 ℃;FID was used and alcohol was selected as extraction a-gent. Results:The calibration curve of borneol showed good linearity in the range of 0.097 5-3.898 4 mg/mL(r=0.999 9);the average recovery(n=6) was 101.0% with RSD of 0.71%. The calibration curve of camphor showed good linearity in the range of 1.041-20.82 μg/mL(r=0.999 5); the average recovery(n=6) was 100.4% with RSD of 1.4%. Conclusion: GC is simple, sensitive with high specificity, and can be used in the quality control of Niuhuang Jiangya tablet.
