CAJ | 학술논문

目的：分析syf2在非小细胞肺癌中的表达情况及其与临床病理参数之间的关系。方法：Western Blot分析6对非小细胞肺癌组织和癌旁组织中syf2的蛋白表达差异，免疫组化分析89例非小细胞肺癌组织中syf2的表达情况。结果：Syf2在非小细胞肺癌组织中表达较癌旁组织高；syf2在非小细胞肺癌组织中的表达情况与肿瘤的分化程度及临床分级显著相关(P<0.05)，与年龄、性别、肿瘤大小、组织学类型及肿瘤的淋巴结转移无相关性。结论：Syf2的表达与非小细胞肺癌的进展相关，提示syf2可能是非小细胞肺癌不良预后的一个指标。
목적：분석syf2재비소세포폐암중적표체정황급기여림상병리삼수지간적관계。방법：Western Blot분석6대비소세포폐암조직화암방조직중syf2적단백표체차이，면역조화분석89례비소세포폐암조직중syf2적표체정황。결과：Syf2재비소세포폐암조직중표체교암방조직고；syf2재비소세포폐암조직중적표체정황여종류적분화정도급림상분급현저상관(P<0.05)，여년령、성별、종류대소、조직학류형급종류적림파결전이무상관성。결론：Syf2적표체여비소세포폐암적진전상관，제시syf2가능시비소세포폐암불량예후적일개지표。
Objective:To analyse expression of syf2 in non-small cell lung cancer and the correlation between expression of syf2 and clinicopathologic variables. Methods:Western Blot was used to detect the expression of syf2 in 6 pairs tumor tissues and adjacent nontumorous tissues, immunohistochemistry technique was performed to analyse expression of syf2 in 89 lung cancer samples. Results:Expression of syf2 was up-regulated in lung cancer tissues than in adjacent nontumorous tissues;ex-pression of syf2 had a positive correlation with clinical stage and histological differentiation , but no correlation was found be-tween the presence of syf2 and other factors such as age, sex, and lymph node status. Conclusion:The level of syf2 was relat-ed to the progression of lung cancer and it might serve as a potential marker to evaluate the prognosis of lung cancer.