CAJ | 학술논문

目的：探讨环境因素和CYP2 E1基因rs8192775位点以及二者交互作用与汉族人群胃癌的关系。方法：采用1∶1病例对照研究，选择经病理确诊的汉族原发性胃癌新发患者330例及其对照进行流行病学资料调查。应用多重高温连接酶检测反应技术（ iMLDR）检测rs8192775位点基因型并分析环境因素、rs8192775位点多态性及其基因-环境的交互作用与胃癌的关系。结果：胃癌的环境危险因素为消化系统疾病史、肿瘤家族史、三餐不定时、喜食烟熏煎炸食品和精神压抑，保护因素为喜食新鲜水果。病例、对照组之间基因型频率的差异有统计学意义（ P＜0.05）。环境因素与rs8192775在胃癌的发生中均存在显著的交互作用（ Pint ＜0.05）。结论：消化系统疾病史、肿瘤家族史、喜食新鲜水果、精神压抑与rs8192775位点存在交互作用，增加易感个体胃癌的发生风险。
목적：탐토배경인소화CYP2 E1기인rs8192775위점이급이자교호작용여한족인군위암적관계。방법：채용1∶1병례대조연구，선택경병리학진적한족원발성위암신발환자330례급기대조진행류행병학자료조사。응용다중고온련접매검측반응기술（ iMLDR）검측rs8192775위점기인형병분석배경인소、rs8192775위점다태성급기기인-배경적교호작용여위암적관계。결과：위암적배경위험인소위소화계통질병사、종류가족사、삼찬불정시、희식연훈전작식품화정신압억，보호인소위희식신선수과。병례、대조조지간기인형빈솔적차이유통계학의의（ P＜0.05）。배경인소여rs8192775재위암적발생중균존재현저적교호작용（ Pint ＜0.05）。결론：소화계통질병사、종류가족사、희식신선수과、정신압억여rs8192775위점존재교호작용，증가역감개체위암적발생풍험。
Objective:To determine the association of CYP2E1 gene rs8192775 polymorphism and interaction of gene-environment with the susceptibility of gastric cancer in Han nationality .Methods:A case-control study was conducted to collect 330 new cases of primary gastric cancer and control of epidemiological data and clinical pathology .To apply conditional Logistic regression analysis for environment influence factors in Han population of Nanjing city, multiple heat ligase detection reaction technology (iMLDR) was applied to detect rs8192775, using crossover analysis method to analyse the interaction of SNPs locus and the environment risk factors .Results: The environmental risk factors concluded history of digestive disease , family history of cancer , irregular meals , smoked fried foods and mental depression , fresh fruits were protective factors .The differences of genotype frequency between two groups were statistically significant ( P <0.05 ) . The environment factors with rs 8192775 had significant interaction in the occurrence of gastric cancer (Pint <0.05).Conclusion:The interaction of rs8192775 polymorphism and environmental risk factors happens in gastric cancer .