CAJ | 학술논문

目的：探讨ABCB1基因rs1045642位点多态性对抗抑郁剂文拉法辛疗效的影响。方法：纳入统计的89例抑郁症患者服用抗抑郁剂文拉法辛75～150 mg并随访6周，其中88例随访8周。使用汉密尔顿抑郁17项量表（ HAMD-17）评定抑郁症状的严重程度和治疗效果。采用基因芯片检测ABCB1基因的单核苷酸多态性（ SNPs） rs1045642，并通过Unphased3.0.13软件分析rs1045642位点与文拉法辛疗效的关联性。结果：（1）6周有效组和无效组间在性别、年龄、教育程度、家族史、发病次数及HAMD-17项基线分数之间差异无统计学意义（均P＞0.05）。（2）8周痊愈组和未痊愈组间性别、年龄、教育程度、家族史、发病次数及HAMD-17项基线评分之间差异无统计学意义（均 P ＞0.05）。（3）单个位点的关联分析发现， ABCB1基因rs1045642位点的基因型和等位基因分布频率在有效组、无效组间和痊愈组、非痊愈组间差异无统计学意义（均P＞0.05）。结论：ABCB1基因rs1045642位点多态性与抗抑郁剂文拉法辛疗效无显著相关，尚需在更加同质、更大样本中进一步验证。
목적：탐토ABCB1기인rs1045642위점다태성대항억욱제문랍법신료효적영향。방법：납입통계적89례억욱증환자복용항억욱제문랍법신75～150 mg병수방6주，기중88례수방8주。사용한밀이돈억욱17항량표（ HAMD-17）평정억욱증상적엄중정도화치료효과。채용기인심편검측ABCB1기인적단핵감산다태성（ SNPs） rs1045642，병통과Unphased3.0.13연건분석rs1045642위점여문랍법신료효적관련성。결과：（1）6주유효조화무효조간재성별、년령、교육정도、가족사、발병차수급HAMD-17항기선분수지간차이무통계학의의（균P＞0.05）。（2）8주전유조화미전유조간성별、년령、교육정도、가족사、발병차수급HAMD-17항기선평분지간차이무통계학의의（균 P ＞0.05）。（3）단개위점적관련분석발현， ABCB1기인rs1045642위점적기인형화등위기인분포빈솔재유효조、무효조간화전유조、비전유조간차이무통계학의의（균P＞0.05）。결론：ABCB1기인rs1045642위점다태성여항억욱제문랍법신료효무현저상관，상수재경가동질、경대양본중진일보험증。
Objective: To investigate the role of ABCB1 rs1045642 polymorphism in antidepressant response . Methods:Eighty-nine Chinese Han patients received venlafaxine 75-150 mg for at least 6 weeks,of which 88 cases were followed up for 8 weeks.The Hamilton depression scale-17(HAMD-17) was used to evaluate the severity of depressive symptoms and the therapeutic effects .The single nucleotide polymorphisms ( SNPs ) rs1045642 of ABCB1 gene was detected using gene chips , then the associations of single locus with treatment response were analyzed using Unphased 3.0.13.Results: (1) There were no significant differences of gender ,age,years of education,family history, episode times, and the baseline scores of HAMD-17 between responders and non-responders (all P>0.05).(2) There were also no significant differences of gender ,age,years of education,family history ,episode times and baseline scores of HAMD-17 between remitters and non-remitters ( all P >0.05 ) . (3) Single locus association analysis: The SNPs rs1045642 genotype and allele distribution frequency of ABCB1 gene between responders and non-responders and between remitters and non-remitters had no significant differences ( all P>0.05 ) .Conclusion:There is no ABCB1 rs1045642 polymorphism associated with antidepressant response , it require replication in more homogeneous and larger samples .