CAJ | 학술논문

目的：观察进展期胃癌患者行新辅助化疗后的肝脏微环境的变化，评估术前动脉介入化疗的安全性。方法：收集小于70岁的胃癌患者60例，随机入组分为对照组、术前动脉介入化疗组和术前静脉化疗组，入院后常规检查肝功能，化疗后第1、3、7天抽取外周血了解化疗药物对肝脏功能的影响，术中收集正常肝组织观察术前新辅助化疗对肝脏结构的改变。结果：与术前静脉化疗组相比较，术前动脉介入化疗组光镜及电镜下肝脏细胞结构变化无显著差异，两组肝功能均在正常范围内；治疗组与对照组相比较，肝脏细胞结构发生变化，治疗后肝功能轻度异常。结论：术前动脉介入化疗后，患者肝功能及肝脏微结构无明显异常。
목적：관찰진전기위암환자행신보조화료후적간장미배경적변화，평고술전동맥개입화료적안전성。방법：수집소우70세적위암환자60례，수궤입조분위대조조、술전동맥개입화료조화술전정맥화료조，입원후상규검사간공능，화료후제1、3、7천추취외주혈료해화료약물대간장공능적영향，술중수집정상간조직관찰술전신보조화료대간장결구적개변。결과：여술전정맥화료조상비교，술전동맥개입화료조광경급전경하간장세포결구변화무현저차이，량조간공능균재정상범위내；치료조여대조조상비교，간장세포결구발생변화，치료후간공능경도이상。결론：술전동맥개입화료후，환자간공능급간장미결구무명현이상。
Objective: To study the changes of liver microenvironment in patients with gastric cancer after preoperative regional artery chemotherapy , evaluate the safety of preoperative arterial interventional chemotherapy . Methods:Sixty patients with gastric cancer were collected , which less than 70-year-old.Patients were divided into control group , preoperative regional artery chemotherapy group and preoperative intravenous chemotherapy group , during the surgery we collected gastric carcinoma tissues and normal liver tissue .The changes of cancer tissue and the liver structure were observed .The expressions of C-Met/HGF were detected .Implementation chemotherapy of the first, third and seventh days , peripheral venous blood was respectively collected , which in order to understand the effects of chemotherapy drugs on liver function .Results: By comparison to preoperative intravenous chemotherapy group, in the preoperative regional artery chemotherapy group , tumor necrosis was obviously , the liver structure changes had no significant differences under the light microscope and electron microscope , liver functions were within the normal ranges .The treatment group compared with control group , liver cell structure changed , mild abnormal liver function after treatment .Conclusion: Patients with preoperative arterial interventional chemotherapy have no obvious abnormal liver function and liver microstructure .