分析仪器
分析儀器
분석의기
ANALYTICAL INSTRUMENTATION
2013年
6期
11-14
,共4页
分光光度法%荷移反应%氯唑西林钠%四氯对苯醌
分光光度法%荷移反應%氯唑西林鈉%四氯對苯醌
분광광도법%하이반응%록서서림납%사록대분곤
spectrophotometry%p-chloranil%charge transfer reation%cloxacillin sodium
研究了在乙醇溶液中，氯唑西林钠与与四氯对苯醌发生荷移反应，生成稳定的1∶1络合物，最大吸收波长为426.2nm ，线性范围40～600μg/mL ，表观摩尔吸光系数ε＝3.76×102 L.mol-1.cm-1。回收率在98.61％～100.4％范围内，相对标准偏差≤2.14％。该方法简便、快速可用于测定药物制剂中氯唑西林钠的含量，结果满意。
研究瞭在乙醇溶液中，氯唑西林鈉與與四氯對苯醌髮生荷移反應，生成穩定的1∶1絡閤物，最大吸收波長為426.2nm ，線性範圍40～600μg/mL ，錶觀摩爾吸光繫數ε＝3.76×102 L.mol-1.cm-1。迴收率在98.61％～100.4％範圍內，相對標準偏差≤2.14％。該方法簡便、快速可用于測定藥物製劑中氯唑西林鈉的含量，結果滿意。
연구료재을순용액중，록서서림납여여사록대분곤발생하이반응，생성은정적1∶1락합물，최대흡수파장위426.2nm ，선성범위40～600μg/mL ，표관마이흡광계수ε＝3.76×102 L.mol-1.cm-1。회수솔재98.61％～100.4％범위내，상대표준편차≤2.14％。해방법간편、쾌속가용우측정약물제제중록서서림납적함량，결과만의。
A new spectrophotometric method was developed for determination of cloxacillin sodium.It is based on a reaction of charge transfer with p-chloranil in ethanol medium. The composition of complex of cloxacillin sodium with p-chloranil both are 1∶1.The calibration curves are linear in the concentration range of 40-600 μg/mL.The complexe maximum absorption is at 426.2nm.The apparent molar absorptivi-ty of complex isε=3.76 × 102 L.mol-1.cm -1.T he recovery is 98.61%-100.4% and the relative standard deviation is≤2.14%.The proposed method has been applied to the determination of cloxacillin sodium for injection and capsules form with satisfactory results.
