CAJ | 학술논문

肺纤维化是临床常见的呼吸系统疾病，目前其发病机制尚不清楚，本文以凝血机制为切入点，探讨凝血-纤溶系统在肺纤维化疾病发展过程中的异常变化，并从中医角度观察活血化瘀药对肺间质纤维化有效治疗作用，认为针对凝血纤溶异常进行的抗凝治疗可能成为临床治疗间质性肺疾病新的靶标，为临床治疗肺间质纤维化提供新思路及理论支持。
폐섬유화시림상상견적호흡계통질병，목전기발병궤제상불청초，본문이응혈궤제위절입점，탐토응혈-섬용계통재폐섬유화질병발전과정중적이상변화，병종중의각도관찰활혈화어약대폐간질섬유화유효치료작용，인위침대응혈섬용이상진행적항응치료가능성위림상치료간질성폐질병신적파표，위림상치료폐간질섬유화제공신사로급이론지지。
Pulmonary fibrosis is a common respiratory disease in the clinic. Until now, the pathogenesis is still un-clear. Using clotting mechanism as the starting point, this article mainly explored abnormal changes of the coagula-tion - fibrinolysis system in the development of pulmonary fibrosis. The effective treatment through the activation of blood circulation to remove stasis in traditional Chinese medicine (TCM) point of view was also observed on the man-agement of interstitial pulmonary fibrosis. It considered that to carry out the anticoagulant therapy for abnormal coag-ulation, which may become a new target for clinical treatment of interstitial lung diseases. It provided new ideas and theoretical support for clinical treatment of pulmonary interstitial fibrosis.