CAJ | 학술논문

目的：优选戊己胃漂浮缓释片制剂的最优处方配比。方法：以多个组分释放度为评价指标，选择辅料HPMC（K100M）、PEG 6000、NaHCO3、十六醇等4个因素，建立正交试验进行考察，干粉压片，优化制剂体外释药及漂浮性能。结果：选择以35%HPMC、5%PEG 6000、10%NaHCO3、15%十六醇、10%MCC及25%的主药，作为戊己胃漂浮缓释片处方的最优制剂配方。结论：所制备的戊己胃内漂浮型缓释片具有缓释、漂浮时间长的优点，制备工艺具有良好的可操作性。
목적：우선무기위표부완석편제제적최우처방배비。방법：이다개조분석방도위평개지표，선택보료HPMC（K100M）、PEG 6000、NaHCO3、십륙순등4개인소，건립정교시험진행고찰，간분압편，우화제제체외석약급표부성능。결과：선택이35%HPMC、5%PEG 6000、10%NaHCO3、15%십륙순、10%MCC급25%적주약，작위무기위표부완석편처방적최우제제배방。결론：소제비적무기위내표부형완석편구유완석、표부시간장적우점，제비공예구유량호적가조작성。
This study was aimed to screen out an optimal pharmaceutical formulation of Wuji Gastric Floating Sus-tained-release Tablets. With multicomponents of release for index, the extra-floating ability of the tablets was stud-ied with the orthogonal test of four excipients, which were HPMC (K100M), PEG 6000, sodium bicarbonate and se-tanol. The results showed that the combined optimal pharmaceutical formulation was 35% HPMC, 5% PEG 6000, 10% sodium bicarbonate, 15% setanol, 10% MCC and 25% main drug. It was concluded that Wuji Gastric Floating Sustained-release Tablets had the characteristics of slow-release and long floating duration which comply with re-quirements of formulation design. This preparation technique is with good maneuverability.