CAJ | 학술논문

目的：观察对药酸枣仁-合欢花对抑郁症患者认知功能及血清脑源性神经营养因子（BDNF）水平的影响。方法：收集抑郁症患者60例，随机分为两组。酸枣仁-合欢花组30例，服用酸枣仁-合欢花汤剂；盐酸文拉法辛组30例，口服盐酸文拉法辛缓释片。两组分别于治疗前及治疗6周后进行汉密顿抑郁量表（HAMD量表）评分、威斯康星卡片分类（WCST）测试及血清BDNF检测。结果：治疗前后两组间HAMD评分、WCST（总应答数、完成分类数、正确应答数、持续错误数、随机错误数）得分、血清BDNF（神经营养因子）水平无显著性差异。与治疗前比较，治疗后两组患者HAMD评分、总应答数、完成分类数、正确应答数及血清BDNF水平明显上升，持续错误数、随机错误数明显减少，差异均有统计学意义（P<0.05或P<0.01）。结论：酸枣仁-合欢花汤剂具有抗抑郁功效，并能够改善抑郁患者的认识功能，其作用机制可能与提高血清BDNF水平有关。
목적：관찰대약산조인-합환화대억욱증환자인지공능급혈청뇌원성신경영양인자（BDNF）수평적영향。방법：수집억욱증환자60례，수궤분위량조。산조인-합환화조30례，복용산조인-합환화탕제；염산문랍법신조30례，구복염산문랍법신완석편。량조분별우치료전급치료6주후진행한밀돈억욱량표（HAMD량표）평분、위사강성잡편분류（WCST）측시급혈청BDNF검측。결과：치료전후량조간HAMD평분、WCST（총응답수、완성분류수、정학응답수、지속착오수、수궤착오수）득분、혈청BDNF（신경영양인자）수평무현저성차이。여치료전비교，치료후량조환자HAMD평분、총응답수、완성분류수、정학응답수급혈청BDNF수평명현상승，지속착오수、수궤착오수명현감소，차이균유통계학의의（P<0.05혹P<0.01）。결론：산조인-합환화탕제구유항억욱공효，병능구개선억욱환자적인식공능，기작용궤제가능여제고혈청BDNF수평유관。
This study was aimed to observe effects of herbal pair of semen Ziziphi Spinosae (SZS) and A lbizia Julib-rissin flower (AJF) on cognitive function and serum BDNF among depression patients. A total of 60 depression pa-tients were enrolled and randomly divided into two groups. In the SZS-AJF group, 30 patients were administered with SZS-AJF decoction. In the control group, 30 patients were administered with venlafaxine hydrochloride sus-tained-release tablets. Hamilton Depression Rating Scale (HAMD), Wisconsin Card Sorting Test (WCST), and the serum-brain derived neurotrophic factor (BDNF) were detected before treatment and after six weeks of treatment. The results showed that there were no significant differences on the HAMD score, WCST (Response Administered (Ra), Categories Completed (Cc), Correct Responses (Cr), Perseverative Errors (Pe), Non-perseverative Errors (Npe)), serum BDNF before and after treatment between two groups. Compared with pretreatment, HAMD score, Ra, Cc, Cr, serum BDNF were increased after treatment in both groups. The Pe and Npe were decreased after treatment. There was sta-tistical significance between pretreatment and posttreatment (P< 0.05, or P< 0.01). It was concluded that the herbal pair of SZS-AJF has anti-depressant effect. It can improve cognitive function of depression patients. The anti-de-pressant mechanism of herbal pair of SZS-AJF may be related to the increasing of serum BDNF level.