CAJ | 학술논문

microRNA（简称miRNA）能通过诱导mRNA裂解或抑制mRNA翻译从而在转录后水平调控基因表达，参与细胞发育、增殖、分化、凋亡等一系列重要生物学进程。近期研究发现miRNA对靶基因的异常调控可能参与肿瘤耐药，有望成为重要的肿瘤耐药相关分子标记物及治疗靶点。中药及其有效成分可影响miRNA进而调控相应靶蛋白和靶基因介导肿瘤多药耐药，为中药逆转多药耐药的机制研究提供新思路。
microRNA（간칭miRNA）능통과유도mRNA렬해혹억제mRNA번역종이재전록후수평조공기인표체，삼여세포발육、증식、분화、조망등일계렬중요생물학진정。근기연구발현miRNA대파기인적이상조공가능삼여종류내약，유망성위중요적종류내약상관분자표기물급치료파점。중약급기유효성분가영향miRNA진이조공상응파단백화파기인개도종류다약내약，위중약역전다약내약적궤제연구제공신사로。
MicroRNA (miRNA for short) can induce mRNA cleavage or inhibit mRNA translation and regulate gene expression in the post-transcriptional level, which involves cell development, proliferation, differentiation, apoptosis, and a series of important biological processes. Recent studies have found that the abnormal regulation of miRNA's target genes may be involved in tumor resistance. And it is expected to become important tumor resistance-associat-ed molecular markers and therapeutic targets. Mechanism of traditional Chinese medicine (TCM) and its active ingre-dients can affect miRNA to regulate target proteins and target genes mediated tumor multidrug resistance. It can pro-vide new ideas for the mechanism of reversing multidrug resistance by TCM.