中国药师
中國藥師
중국약사
CHINA PHARMACIST
2014年
5期
842-844
,共3页
泮托拉唑%多潘立酮%铝碳酸镁%胆汁反流性胃炎%联合用药
泮託拉唑%多潘立酮%鋁碳痠鎂%膽汁反流性胃炎%聯閤用藥
반탁랍서%다반립동%려탄산미%담즙반류성위염%연합용약
Pantoprazole%Domperidone%Hydrotalcite%Bile reflux gastritis%Drug combination
目的：观察联合应用多潘立酮、泮托拉唑和铝碳酸镁治疗胆汁反流性胃炎( BRG)的疗效，探讨药物作用机制。方法：80例BRG患者随机分为观察组与对照组各40例。观察组给予泮托拉唑胶囊、铝碳酸镁片、多潘立酮片治疗，对照组给予铝碳酸镁片、多潘立酮片治疗。4周后观察两组的治疗效果。结果：治疗后，观察组有效率为92.5%，高于对照组的62.5%( P<0.05)；两组治疗后胃黏膜充血、水肿、糜烂情况均有明显改善(P<0.05)，且观察组较对照组改善更显著(P<0.05)；两组治疗后胃液胆酸含量、胃酸分泌量均较前明显降低(P<0.05)，而观察组胃酸分泌量明显更低于对照组(P<0.05)。结论：多潘立酮、泮托拉唑和铝碳酸镁片联合用药可有效减轻患者的临床症状，减少胃酸分泌，明显改善胃镜下黏膜炎症，临床效果明显优于多潘立酮和铝碳酸镁两药联用。
目的：觀察聯閤應用多潘立酮、泮託拉唑和鋁碳痠鎂治療膽汁反流性胃炎( BRG)的療效，探討藥物作用機製。方法：80例BRG患者隨機分為觀察組與對照組各40例。觀察組給予泮託拉唑膠囊、鋁碳痠鎂片、多潘立酮片治療，對照組給予鋁碳痠鎂片、多潘立酮片治療。4週後觀察兩組的治療效果。結果：治療後，觀察組有效率為92.5%，高于對照組的62.5%( P<0.05)；兩組治療後胃黏膜充血、水腫、糜爛情況均有明顯改善(P<0.05)，且觀察組較對照組改善更顯著(P<0.05)；兩組治療後胃液膽痠含量、胃痠分泌量均較前明顯降低(P<0.05)，而觀察組胃痠分泌量明顯更低于對照組(P<0.05)。結論：多潘立酮、泮託拉唑和鋁碳痠鎂片聯閤用藥可有效減輕患者的臨床癥狀，減少胃痠分泌，明顯改善胃鏡下黏膜炎癥，臨床效果明顯優于多潘立酮和鋁碳痠鎂兩藥聯用。
목적：관찰연합응용다반립동、반탁랍서화려탄산미치료담즙반류성위염( BRG)적료효，탐토약물작용궤제。방법：80례BRG환자수궤분위관찰조여대조조각40례。관찰조급여반탁랍서효낭、려탄산미편、다반립동편치료，대조조급여려탄산미편、다반립동편치료。4주후관찰량조적치료효과。결과：치료후，관찰조유효솔위92.5%，고우대조조적62.5%( P<0.05)；량조치료후위점막충혈、수종、미란정황균유명현개선(P<0.05)，차관찰조교대조조개선경현저(P<0.05)；량조치료후위액담산함량、위산분비량균교전명현강저(P<0.05)，이관찰조위산분비량명현경저우대조조(P<0.05)。결론：다반립동、반탁랍서화려탄산미편연합용약가유효감경환자적림상증상，감소위산분비，명현개선위경하점막염증，림상효과명현우우다반립동화려탄산미량약련용。
Objective:To observe the curative effects of the combined application of domperidone, pantoprazole and hydrotalcite tablets in the treatment of bile reflux gastritis ( BRG) and explore the underlying mechanism. Methods:Totally 80 patients with BRG were randomly divided into the treatment group and the control group with 40 cases in each. The treatment group was received panto-prazole, hydrotalcite tablets and domperidone, and the control group was treated by hydrotalcite tablets and domperidone. The efficacy was observed in both groups after 4 weeks. Results:The effective rate of symptom relief in the treatment group and the control group was respectively 92. 5% and 62. 5% (P<0. 05). After the 4 week treatment, the gastritis healing rate in the treatment group was higher than that in the control group (P<0. 05). The improvement of gastric mucosal hyperemia, edema and erosion in the treatment group was better than that in the control group with significant difference (P<0. 05). Cholic acid in gastric juice and gastric acid se-cretion were significantly reduced in both groups after the treatment, while the reduction of gastric acid secretion in the treatment group was more notable than that in the control (P<0. 05). Conclusion:Pantoprazole can be used to control BRG, and the combination of the three drugs shows better efficacy in the treatment of BRG.
