CAJ | 학술논문

目的：探讨滥用氯胺酮所引起的泌尿系统损害及诊治方法。方法：回顾性分析56例有滥用氯胺酮史患者的泌尿系统症状、体征、泌尿系统相关检查，根据不同情况予以相关治疗方案的探讨。结果：氯胺酮相关性泌尿系统损害主要症状为下尿路症状( LUTS)，膀胱病理活检表现为不同程度的炎症改变。影像学检查可见不同程度的病变，主要表现为：膀胱容量小，膀胱壁增厚，膀胱挛缩，输尿管狭窄，肾积水。3例患者血清肌酐升高。结论：氯胺酮相关性泌尿系统损害是以下尿路症状( LUTS)为主要临床表现的疾病，疾病早期为可逆性，治疗效果良好，后期继发的膀胱挛缩和肾功能损害是不可逆的，需要引起重视。
목적：탐토람용록알동소인기적비뇨계통손해급진치방법。방법：회고성분석56례유람용록알동사환자적비뇨계통증상、체정、비뇨계통상관검사，근거불동정황여이상관치료방안적탐토。결과：록알동상관성비뇨계통손해주요증상위하뇨로증상( LUTS)，방광병리활검표현위불동정도적염증개변。영상학검사가견불동정도적병변，주요표현위：방광용량소，방광벽증후，방광련축，수뇨관협착，신적수。3례환자혈청기항승고。결론：록알동상관성비뇨계통손해시이하뇨로증상( LUTS)위주요림상표현적질병，질병조기위가역성，치료효과량호，후기계발적방광련축화신공능손해시불가역적，수요인기중시。
Objective:To explore the diagnosis and treatment of ketamine-associated urinary system dysfunction. Methods:Total-ly 56 cases of urinary tract symptoms with the history of ketamine abuse in recent years were retrospectively analyzed. The routine ex-amination and the examination related to the urinary system were given, and individual treatment was undertaken according to different situation. Results: The main symptom of ketamine-asscociated urinary tract dysfunction was lower urinary tract symptom (LUTS). Bladder pathologic biopsy showed different degree of inflammatory change. Imaging examination showed various degree of pathological changes, including reduced bladder capacity, thickened bladder wall, bladder contracture, ureteral stricture and hydronephrosis. Three patients had increased serum creatinine level. Conclusion: Ketamine-asscociated urinary system dysfunction is a disease with LUTS as the main clinical symptom. At the early stage, the disease is reversible with promising treatment outcome. In the progression of the disease, some patients develop irreversible histological changes in the urinary tract, which should be brought to the forefront.