中医药导报
中醫藥導報
중의약도보
GUIDING JOURNAL OF TCM
2013年
11期
80-82
,共3页
邓燚%李欣%邵萌%刘金坤%范钦%王启瑞%蔡红兵(通讯作者)
鄧燚%李訢%邵萌%劉金坤%範欽%王啟瑞%蔡紅兵(通訊作者)
산일%리흔%소맹%류금곤%범흠%왕계서%채홍병(통신작자)
化香树果序%挥发油%气质联用%体外抗肿瘤活性
化香樹果序%揮髮油%氣質聯用%體外抗腫瘤活性
화향수과서%휘발유%기질련용%체외항종류활성
Platycarya strobilacea%Essential oil%GC-MS%Antitumor activity in vitro
目的:研究化香树果序挥发油的化学成分及其体外抗肿瘤活性。方法:采用水蒸气蒸馏法从化香树果序中提取挥发油,通过气相色谱-质谱联用技术对其挥发油成分进行分析;采用MTT法观察其对人肝癌HepG2细胞、人鼻咽癌CNE-2细胞及人宫颈癌HeLa细胞的增殖抑制率及半数抑制浓度(IC50)。结果:从挥发油中共鉴定出28个化合物,占总离子流图峰面积的94.10%,其中含量较高的组分为(Z,Z,Z)-9,12,15-十八碳三烯酸(44.48%)、十六烷酸(23.30%)和斯巴醇(3.20%)等。化香树果序挥发油对人肝癌HepG2细胞、人鼻咽癌CNE-2细胞及人宫颈癌HeLa细胞均表现出不同程度的抑制活性,IC50值分别为848.554、451.835、301.253μg/mL。结论:化香树果序挥发油具有多种活性成分,对人肝癌HepG2细胞、人鼻咽癌CNE2细胞及人宫颈癌HeLa细胞均显示出了一定的抑制活性。
目的:研究化香樹果序揮髮油的化學成分及其體外抗腫瘤活性。方法:採用水蒸氣蒸餾法從化香樹果序中提取揮髮油,通過氣相色譜-質譜聯用技術對其揮髮油成分進行分析;採用MTT法觀察其對人肝癌HepG2細胞、人鼻嚥癌CNE-2細胞及人宮頸癌HeLa細胞的增殖抑製率及半數抑製濃度(IC50)。結果:從揮髮油中共鑒定齣28箇化閤物,佔總離子流圖峰麵積的94.10%,其中含量較高的組分為(Z,Z,Z)-9,12,15-十八碳三烯痠(44.48%)、十六烷痠(23.30%)和斯巴醇(3.20%)等。化香樹果序揮髮油對人肝癌HepG2細胞、人鼻嚥癌CNE-2細胞及人宮頸癌HeLa細胞均錶現齣不同程度的抑製活性,IC50值分彆為848.554、451.835、301.253μg/mL。結論:化香樹果序揮髮油具有多種活性成分,對人肝癌HepG2細胞、人鼻嚥癌CNE2細胞及人宮頸癌HeLa細胞均顯示齣瞭一定的抑製活性。
목적:연구화향수과서휘발유적화학성분급기체외항종류활성。방법:채용수증기증류법종화향수과서중제취휘발유,통과기상색보-질보련용기술대기휘발유성분진행분석;채용MTT법관찰기대인간암HepG2세포、인비인암CNE-2세포급인궁경암HeLa세포적증식억제솔급반수억제농도(IC50)。결과:종휘발유중공감정출28개화합물,점총리자류도봉면적적94.10%,기중함량교고적조분위(Z,Z,Z)-9,12,15-십팔탄삼희산(44.48%)、십륙완산(23.30%)화사파순(3.20%)등。화향수과서휘발유대인간암HepG2세포、인비인암CNE-2세포급인궁경암HeLa세포균표현출불동정도적억제활성,IC50치분별위848.554、451.835、301.253μg/mL。결론:화향수과서휘발유구유다충활성성분,대인간암HepG2세포、인비인암CNE2세포급인궁경암HeLa세포균현시출료일정적억제활성。
Objective: To analyze the chemical constituents of the essential oil from Platycarya strobilacea and investigate the antitumor activity in vitro. Methods: The essential oil of Platycarya strobilacea was extracted by steam distillation. The chem-ical components were separated and analyzed by GC-MS. The proliferations and half inhibition concentration (IC50) were ob-served by MTT assay in hepatocellular carcinoma cell HepG2,nasopharyngeal carcinoma cell CNE2 and cervical carcinoma cell HeLa, which treated with different concentrations of The essential oil of Platycarya strobilacea. Results: There were 28 com-pounds identified and accounted for 94.10% of the peak area from the total ion-current chromatogram. The higher content of components were (Z,Z,Z)-9, 12,15- calendic acid (44.48%), hexadecanoic acid (23.30%) and barbatol (3.20%), et al. The essen-tial oil showed different antitumor activities against the proliferation of HepG2,CNE2 and HeLa cells in concentration-dependent manner. The IC50 values of The essential oil of Platycarya strobilacea against HepG2, CNE2 and HeLa cells were 848.554、451.835、301.253 μg/mL respectively. Conclusion: The essential oil of Platycarya strobilacea contains various constituents which showed antitumor activities on HepG2, CNE2 and HeLa cells in vitro.