CAJ | 학술논문

肿瘤细胞存在能量代谢异常，表现为糖酵解过度活跃，而线粒体有氧代谢削弱，被称为“Warburg效应”。最近的研究表明，肿瘤组织中的代谢异常远比我们之前认识的要复杂。尽管存在旺盛的糖酵解，实际上肿瘤组织仍然保留线粒体有氧代谢。另一方面，线粒体是肿瘤细胞合成代谢的主要场所之一。肿瘤组织还发现存在脂肪酸代谢、氨基酸代谢异常。肿瘤发生过程中，整个代谢网络在瘤基因、抑瘤基因主导下发生重编程，营养组织在代谢网络中的流向和流量被重新定义。肿瘤细胞代谢重编程的法则在于平衡细胞能量需求和合成代谢，以利于生物大分子合成，达到细胞倍增。靶向细胞代谢酶的抗肿瘤治疗，目的并不是干扰肿瘤细胞的能量供应，而是影响其合成代谢速率，从而抑制肿瘤的增殖。
종류세포존재능량대사이상，표현위당효해과도활약，이선립체유양대사삭약，피칭위“Warburg효응”。최근적연구표명，종류조직중적대사이상원비아문지전인식적요복잡。진관존재왕성적당효해，실제상종류조직잉연보류선립체유양대사。령일방면，선립체시종류세포합성대사적주요장소지일。종류조직환발현존재지방산대사、안기산대사이상。종류발생과정중，정개대사망락재류기인、억류기인주도하발생중편정，영양조직재대사망락중적류향화류량피중신정의。종류세포대사중편정적법칙재우평형세포능량수구화합성대사，이리우생물대분자합성，체도세포배증。파향세포대사매적항종류치료，목적병불시간우종류세포적능량공응，이시영향기합성대사속솔，종이억제종류적증식。
Despite seminal studies in the 1920s by Warburg showing a characteristic metabolic pattern for tumors, cancer bioenergetics has otfen been relegated to the backwaters of cancer biology. Recent studies have shown that metabolism in the tumor tissue is far more complicated than we previously knew. Despite vigorous glycolysis, in fact, the tumor tissue still retains mitochondrial aerobic metabolism. Mitochondria is one of the main sites of the biosynthesis process of tumor cells. Recent studies revealed that abnormal fatty acid metabolism. Amino acid metabolism plays a key role in the tumorigenesis. The metabolic network in tumor cells was reprogrammed, leading to nutrition lfux reorganization and re-direction. Metabolism reprogramming in tumor cells facilitates the balance between the needs of energy supply and the synthesis of biological macromolecules. Targeting cell metabolism is not intended to interfere the energy supply of tumor cells but to affect the synthesis of metabolic rate, thereby inhibiting the proliferation of the tumor. hTe review focuses on the importance of metabolic reprogramming in tumor development and cancer therapy. We summarize what is currently known about metabolic reprogramming and establish a framework to understanding its contribution to the altered metabolism of cancer cells.