中南大学学报（医学版）
中南大學學報（醫學版）
중남대학학보（의학판）
JOURNAL OF CENTRAL SOUTH UNIVERSITY (MEDICAL SCIENCES)
2013年
11期
1141-1145
,共5页
孙杨%龙剑虹%王永洁
孫楊%龍劍虹%王永潔
손양%룡검홍%왕영길
单核苷酸多态性%ABCC11%腋臭%耳耵聍
單覈苷痠多態性%ABCC11%腋臭%耳耵聹
단핵감산다태성%ABCC11%액취%이정녕
single nucleotide polymorphism%ATP binding cassette C11%axillary osmidrosis%earwax
目的：研究我国汉族人群ABCC11基因的单核苷酸多态性与腋臭发病的关系。方法：应用高分辨率熔解曲线技术以及产物测序，检测40例腋臭患者及5例正常人ABCC11基因多态性位点rs17822931的基因型。结果：ABCC11基因多态性位点rs17822931的等位基因型检测发现腋臭患者37例为GA型，3例为GG型，5例正常人为AA型。结论：ABCC11基因的不同等位基因型决定腋臭的表型，GG或GA型表现为腋臭，AA型等位基因型则无腋臭。
目的：研究我國漢族人群ABCC11基因的單覈苷痠多態性與腋臭髮病的關繫。方法：應用高分辨率鎔解麯線技術以及產物測序，檢測40例腋臭患者及5例正常人ABCC11基因多態性位點rs17822931的基因型。結果：ABCC11基因多態性位點rs17822931的等位基因型檢測髮現腋臭患者37例為GA型，3例為GG型，5例正常人為AA型。結論：ABCC11基因的不同等位基因型決定腋臭的錶型，GG或GA型錶現為腋臭，AA型等位基因型則無腋臭。
목적：연구아국한족인군ABCC11기인적단핵감산다태성여액취발병적관계。방법：응용고분변솔용해곡선기술이급산물측서，검측40례액취환자급5례정상인ABCC11기인다태성위점rs17822931적기인형。결과：ABCC11기인다태성위점rs17822931적등위기인형검측발현액취환자37례위GA형，3례위GG형，5례정상인위AA형。결론：ABCC11기인적불동등위기인형결정액취적표형，GG혹GA형표현위액취，AA형등위기인형칙무액취。
Objective:To explore the relationship between ABCC11 gene single nucleotide polymorphism (SNP) and the incidence of axillary osmidrosis in Chinese Han population.Methods:The genotype of ABCC11 gene SNP at rs17822931 in 40 patients with axillary osmidrosis and 5 normal Han people was detected and analyzed by high resolution melt and gene sequencing.
<br> Results:hTe detection of the genotype of ABCC11 gene SNP at rs17822931 showed that:37 of the 40 patients were GA genotype and the other 3 were GG genotype, while the 5 normal subjects were AA genotype.
<br> Conclusion:SNP in ABCC11 is the genetic cause of axillary osmidrosis. GG or GA leads to axillary osmidrosis, while AA allele presents the absence of axillary osmidrosis.
