CAJ | 학술논문

目的：观察参松养心胶囊＋通心络胶囊对日本大耳兔心肌梗死模型心脏电生理特性的影响，并探讨其治疗心肌梗死后心律失常的机制。方法24只日本大耳兔随机分为假手术组、模型组、通络组各8只，以前降支动脉结扎术建立心肌梗死模型，通络组于结扎术后给予0?．4 g· kg-1· d-1参松养心原粉＋0．3 g· kg-1· d-1通心络原粉灌胃。8周后，行在体电生理研究。结果与假手术组比较，模型组左心室内、中、外膜层心肌细胞动作电位时限复极90％时间（MAPD90）缩短（ P ＜0．05）；左心室MAPD90缩短（ P ＜0．05）；左心室有效不应期（ERP）延长（ P ＜0．05）；心室颤动（室颤）阈值（VFT）明显降低（ P ＜0．05）。与模型组比较，通络组左心室内、中、外膜层心肌细胞MAPD90延长；左心室MAPD90延长（ P ＜0．05）；ERP缩短（ P ＜0．05）；VFT明显升高（ P ＜0．05）。结论参松养心胶囊联合通心络可延长MAPD90、缩短ERP，通过提高VFT发挥抗心肌梗死后心律失常的作用。
목적：관찰삼송양심효낭＋통심락효낭대일본대이토심기경사모형심장전생리특성적영향，병탐토기치료심기경사후심률실상적궤제。방법24지일본대이토수궤분위가수술조、모형조、통락조각8지，이전강지동맥결찰술건립심기경사모형，통락조우결찰술후급여0?．4 g· kg-1· d-1삼송양심원분＋0．3 g· kg-1· d-1통심락원분관위。8주후，행재체전생리연구。결과여가수술조비교，모형조좌심실내、중、외막층심기세포동작전위시한복겁90％시간（MAPD90）축단（ P ＜0．05）；좌심실MAPD90축단（ P ＜0．05）；좌심실유효불응기（ERP）연장（ P ＜0．05）；심실전동（실전）역치（VFT）명현강저（ P ＜0．05）。여모형조비교，통락조좌심실내、중、외막층심기세포MAPD90연장；좌심실MAPD90연장（ P ＜0．05）；ERP축단（ P ＜0．05）；VFT명현승고（ P ＜0．05）。결론삼송양심효낭연합통심락가연장MAPD90、축단ERP，통과제고VFT발휘항심기경사후심률실상적작용。
Objective To observe the effect of Shensongyangxin capsule plus Tongxinluo capsule on cardiac electro-physiological properties in Japanese big ear rabbit with myocardial infarction model , and investigate the mechanism of treat-ment after myocardial infarction arrhythmia .Methods Twenty-four Japanese big ear rabbits were randomly divided into sham operation group and model group , Tongluo group with 8 rats in each group , before descending artery ligation to establish the model of myocardial infarction , Tongluo group were given 0.4 g· kg-1 · d-1 of Shensongyangxin powder +0.3 g· kg-1 · d-1 Tongxinluo powder through gastric lavage after the ligation of descending artery .After 8 weeks, in vivo electrophysiology were performed .Results Compared with the sham operation group , model group ’ s left ventricle adventitia myocardial cell action potential duration of 90%repolarization time (MAPD 90) is shortened ( P <0.05); left ventricular MAPD 90 also is shortened ( P <0.05);left ventricular effective refractory period (ERP) is prolonged ( P <0.05); ventricular fibrillation (VF) threshold (VFT) decreased significantly ( P <0.05).Compared with the model group,Tongluo group’s left ventricular adventitia myocardial cells MAPD 90 is prolonged;left ventricular MAPD 90 is prolonged ( P <0.05);ERP is shortened (P <0.05);VFT is increased significantly ( P <0.05).Conclusion The Shensongyangxin capsule plus Tongxinluo capsule could prolong MAPD 90 and shorten the ERP ,play the antiarrhythmic effect by increasing VFT after myocardial infarction .