CAJ | 학술논문

目的：观察通心络胶囊辅治腔隙性脑梗死（LI）合并血管性认知功能障碍（VCI）患者的疗效。方法纳入LI合并VCI患者68例，随机分成对照组、治疗组各34例，2组均给予常规治疗，治疗组加用通心络胶囊3粒口服，每天3次，疗程均为4个月，比较2组简易智能精神状态检查量表（ MMSE）评分、日常生活能力（ ADL）评分、纤维蛋白原（ Fg）及血液流变学的改变。结果与治疗前比较，2组治疗后MMSE评分、ADL评分、Fg及血液流变学均有改善（ P ＜0．05），且治疗组MMSE 评分、ADL评分、Fg及还原黏度高切、还原黏度低切、红细胞聚集指数较对照组改善明显（ P ＜0．05），而全血黏度高切、全血黏度低切差异无统计学意义（ P ＞0．05）。治疗组发生不良反应5例（14．7％），对照组发生3例（8．8％），2组比较差异无统计学意义（ P ＞0．05）。结论通心络胶囊不但可改善LI合并VCI患者的认知功能，而且可改善患者Fg、血液流变学，对LI合并VCI患者治疗具有一定的意义。
목적：관찰통심락효낭보치강극성뇌경사（LI）합병혈관성인지공능장애（VCI）환자적료효。방법납입LI합병VCI환자68례，수궤분성대조조、치료조각34례，2조균급여상규치료，치료조가용통심락효낭3립구복，매천3차，료정균위4개월，비교2조간역지능정신상태검사량표（ MMSE）평분、일상생활능력（ ADL）평분、섬유단백원（ Fg）급혈액류변학적개변。결과여치료전비교，2조치료후MMSE평분、ADL평분、Fg급혈액류변학균유개선（ P ＜0．05），차치료조MMSE 평분、ADL평분、Fg급환원점도고절、환원점도저절、홍세포취집지수교대조조개선명현（ P ＜0．05），이전혈점도고절、전혈점도저절차이무통계학의의（ P ＞0．05）。치료조발생불량반응5례（14．7％），대조조발생3례（8．8％），2조비교차이무통계학의의（ P ＞0．05）。결론통심락효낭불단가개선LI합병VCI환자적인지공능，이차가개선환자Fg、혈액류변학，대LI합병VCI환자치료구유일정적의의。
Objective To observe the effect of Tongxinluo capsule on adjuvant treatment of lacunar infarction (LI) complicated with vascular cognitive impairment (VCI).Methods Sixty-eight patients with LI and VCI were enrolled , they were randomly divided into control group and treatment group with 34 cases in each group , 2 groups were given conventional treatment, the treatment group treated with Tongxinluo capsule at 3 capsules, tid, treatment for 4 months, the mini mental state check scale (MMSE) score, ability of daily life (ADL) score, fibrinogen (Fg) and the changes of blood rheology were compared between the 2 groups.Results Compared with pre treatment, the 2 groups after treatment, MMSE score, ADL score, Fg and hemorheology were improved ( P <0.05), and the treatment group’s MMSE score, ADL score, high shear and low shear of Fg and red cell aggregation index better than the control group ( P <0.05), but no significant differences were found in whole blood high shear viscosity and the whole blood low shear viscosity ( P >0.05).The treatment group had 5 cases occurred with adverse reactions (14.7%), the control group occurred in 3 cases (8.8%), the difference between the 2 groups had no statistical significance ( P >0.05).Conclusion It proved that the Tongxinluo capsule could improve cogni-tive function in patients with LI complicated with VCI , also could improve the patients with Fg , blood rheology , it had certain significance for the treatment of LI combined with VCI .