疑难病杂志
疑難病雜誌
의난병잡지
JOURNAL OF DIFFICULT AND COMPLICATED CASES
2014年
10期
1004-1007
,共4页
刘运秋%王丽晔%耿贺梅%刘晓宇%刘小云%兰璇%李宏芬%李倩
劉運鞦%王麗曄%耿賀梅%劉曉宇%劉小雲%蘭璇%李宏芬%李倩
류운추%왕려엽%경하매%류효우%류소운%란선%리굉분%리천
煤矿职工%慢性阻塞性肺疾病%白介素-1β%基因多态性%男性
煤礦職工%慢性阻塞性肺疾病%白介素-1β%基因多態性%男性
매광직공%만성조새성폐질병%백개소-1β%기인다태성%남성
Coal mine worker%Chronic obstructive pulmonary disease%Interleukin-1β%Gene polymorphism%Male
目的:探讨白细胞介素-1β(IL-1β)基因-511和+3954多态性与男性煤矿职工慢性阻塞性肺疾病( COPD)的相关性。方法收集2009年1月-2013年6月河北联合大学附属开滦总医院呼吸科门诊筛查的234例煤矿职工COPD患者(煤矿职工COPD组)及250例同期健康对照人群(健康对照组),用酶联免疫吸附试验(ELISA)检测血清IL-1β水平,应用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)方法检测-511C/T,+3954C/T位点的基因型。结果煤矿职工COPD组的血清IL-1β水平为(32.98±0.42)ng/ml,健康对照组为(2.76±0.18)ng/ml,2组间差异具有统计学意义( P <0.01)。煤矿职工COPD组IL-1β-511的CC、CT和TT基因型频率分别为20.1%、62.8%和17.1%,健康对照组分别为21.6%、60.4%和18.0%,2组相比差异无统计学意义( P >0.05)。煤矿职工COPD组IL-1β+3954 CC、CT和TT基因型频率分别为83.8%、16.2%和0,健康对照组分别为86.8%、13.2%和0,2组相比无统计学意义( P >0.05)。2组人群IL-1β-511,+3954等位基因频率比较差异无统计学差异( P均>0.05)。结论煤矿职工COPD组血清IL-1β水平高于健康对照组, IL-1β-511、+3954的基因型频率与等位基因频率与煤矿职工COPD的发生无明显相关性。
目的:探討白細胞介素-1β(IL-1β)基因-511和+3954多態性與男性煤礦職工慢性阻塞性肺疾病( COPD)的相關性。方法收集2009年1月-2013年6月河北聯閤大學附屬開灤總醫院呼吸科門診篩查的234例煤礦職工COPD患者(煤礦職工COPD組)及250例同期健康對照人群(健康對照組),用酶聯免疫吸附試驗(ELISA)檢測血清IL-1β水平,應用聚閤酶鏈反應-限製性片段長度多態性(PCR-RFLP)方法檢測-511C/T,+3954C/T位點的基因型。結果煤礦職工COPD組的血清IL-1β水平為(32.98±0.42)ng/ml,健康對照組為(2.76±0.18)ng/ml,2組間差異具有統計學意義( P <0.01)。煤礦職工COPD組IL-1β-511的CC、CT和TT基因型頻率分彆為20.1%、62.8%和17.1%,健康對照組分彆為21.6%、60.4%和18.0%,2組相比差異無統計學意義( P >0.05)。煤礦職工COPD組IL-1β+3954 CC、CT和TT基因型頻率分彆為83.8%、16.2%和0,健康對照組分彆為86.8%、13.2%和0,2組相比無統計學意義( P >0.05)。2組人群IL-1β-511,+3954等位基因頻率比較差異無統計學差異( P均>0.05)。結論煤礦職工COPD組血清IL-1β水平高于健康對照組, IL-1β-511、+3954的基因型頻率與等位基因頻率與煤礦職工COPD的髮生無明顯相關性。
목적:탐토백세포개소-1β(IL-1β)기인-511화+3954다태성여남성매광직공만성조새성폐질병( COPD)적상관성。방법수집2009년1월-2013년6월하북연합대학부속개란총의원호흡과문진사사적234례매광직공COPD환자(매광직공COPD조)급250례동기건강대조인군(건강대조조),용매련면역흡부시험(ELISA)검측혈청IL-1β수평,응용취합매련반응-한제성편단장도다태성(PCR-RFLP)방법검측-511C/T,+3954C/T위점적기인형。결과매광직공COPD조적혈청IL-1β수평위(32.98±0.42)ng/ml,건강대조조위(2.76±0.18)ng/ml,2조간차이구유통계학의의( P <0.01)。매광직공COPD조IL-1β-511적CC、CT화TT기인형빈솔분별위20.1%、62.8%화17.1%,건강대조조분별위21.6%、60.4%화18.0%,2조상비차이무통계학의의( P >0.05)。매광직공COPD조IL-1β+3954 CC、CT화TT기인형빈솔분별위83.8%、16.2%화0,건강대조조분별위86.8%、13.2%화0,2조상비무통계학의의( P >0.05)。2조인군IL-1β-511,+3954등위기인빈솔비교차이무통계학차이( P균>0.05)。결론매광직공COPD조혈청IL-1β수평고우건강대조조, IL-1β-511、+3954적기인형빈솔여등위기인빈솔여매광직공COPD적발생무명현상관성。
Objective To investigate the relationship between interleukin-1 beta ( IL-1β)-511 gene and +3954 pol-ymorphism and male coal mine workers with chronic obstructive pulmonary disease ( COPD) .Methods From January 2009 to June 2013 , collected the Hebei United University affiliated Kailuan General Hospital Outpatient Department ’ s respiration screening COPD patients (234 cases of coal mine workers as coal mine workers COPD group ) and 250 cases of healthy con-trols (healthy control group), using enzyme linked immunosorbent assay (ELISA) to detect serum IL-1βlevel, polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) method to detect -511C/T, genotype +3954C/T sites. Results The coal mine worker group COPD serum IL-1βlevel was (3.98 ±0.42 ) ng/ml, the healthy control group was (2.76 ±0.18) ng/ml, with statistically significant difference between the 2 groups ( P <0.01).Coal mine worker group COPD IL-1β-511 CC, CT and TT genotypes were 20.1%, 62.8%and 17.1%, healthy control group were 21.6%, 60.4%and 18.0%, compared between the 2 groups, there was no statistical significance ( P >0.05).Coal mine worker group COPD IL-1β+3954 , CC, CT and TT genotypes were 83.8%, 16.2%and 0, healthy control group were 86.8%, 13.2% and 0, compared between the 2 groups, there was no statistical significance ( P >0.05),there were no significant differences in the frequency of 2 groups’ IL-1β-511, +3954 allele ( P >0.05).Conclusion Coal mine worker group COPD serum IL-1βlevels higher than the healthy control group .IL-1βand genotype frequency of -511 , the incidence of +3954 and allele fre-quency have no obvious correlation with coal mine workers ’ COPD.