CAJ | 학술논문

目的：观察阿托伐他汀联合强骨胶囊治疗老年2型糖尿病性骨质疏松症的疗效。方法100例老年2型糖尿病性骨质疏松症患者按数字法随机分为2组，每组50例。治疗组口服阿托伐他汀和强骨胶囊；对照组给予口服强骨胶囊，2组均予以联合服用碳酸钙/维生素D3，均服用药物6个月。观察2组临床疗效，评价治疗前和治疗后的疼痛评分情况及骨密度（BMD）情况。结果与治疗前比较，2组治疗后空腹血糖（FPG）、餐后2 h血糖（2 hPG）、糖化血红蛋白（HbA1c）均有改善，差异有统计学意义（ P ＜0 f．05）；而BMI无显著变化（ P ＞0．05），2组比较差异亦无统计学意义（ P ＞0．05）。与治疗前比较，2组疼痛评分均下降[分别为（7．96±2．73）分 vs．（3．68±1．76）分、（7．89±2．90）分vs．（5．26±1．65）分， P均＜0．01]；且治疗组下降幅度高于对照组（ P ＜0．05）；与治疗前比较，治疗后治疗组BMD明显改善（ P ＜0．05），而对照组无显著改善（ P ＞0．05），且治疗组治疗后BMD 改善优于对照组（ P ＜0．05）。结论阿托伐他汀联合强骨胶囊治疗老年2型糖尿病性骨质疏松症具有协同作用。
목적：관찰아탁벌타정연합강골효낭치료노년2형당뇨병성골질소송증적료효。방법100례노년2형당뇨병성골질소송증환자안수자법수궤분위2조，매조50례。치료조구복아탁벌타정화강골효낭；대조조급여구복강골효낭，2조균여이연합복용탄산개/유생소D3，균복용약물6개월。관찰2조림상료효，평개치료전화치료후적동통평분정황급골밀도（BMD）정황。결과여치료전비교，2조치료후공복혈당（FPG）、찬후2 h혈당（2 hPG）、당화혈홍단백（HbA1c）균유개선，차이유통계학의의（ P ＜0 f．05）；이BMI무현저변화（ P ＞0．05），2조비교차이역무통계학의의（ P ＞0．05）。여치료전비교，2조동통평분균하강[분별위（7．96±2．73）분 vs．（3．68±1．76）분、（7．89±2．90）분vs．（5．26±1．65）분， P균＜0．01]；차치료조하강폭도고우대조조（ P ＜0．05）；여치료전비교，치료후치료조BMD명현개선（ P ＜0．05），이대조조무현저개선（ P ＞0．05），차치료조치료후BMD 개선우우대조조（ P ＜0．05）。결론아탁벌타정연합강골효낭치료노년2형당뇨병성골질소송증구유협동작용。
Objective To observe the curative effect of atorvastatin combined with Qianggu capsules in the treatment ofelderlypatientswithtype2diabeticosteoporosis.Methods 100casesofelderlypatientswithtype2diabeticosteoporosis were randomly divided into 2 groups, 50 cases in each group.The treatment group received oral atorvastatin and Qianggu cap-sules;the control group was given orally Qianggu capsules, 2 groups were treated with combined use of calcium carbonate Vi-tamin D3 , both groups were taking medication for 6 months.Observed the clinical curative effect of the pain scores and the bone density evaluation before and after treatment (BMD) condition in the 2 groups.Results Compared with pre and post treatment, fasting plasma glucose(FPG),postprandial 2 h blood glucose(2 hPG),HbA1c in the 2 groups were improved, the difference was statistically significant ( P <0.05), and BMI showed no significant change ( P >0.05), the difference be-tween the 2 groups has no statistical significance ( P >0.05).Compared with before treatment ,2 groups’ pain scores were decreased [(7.96 ±2.73) vs.(3.68 ±1.76), (7.89 ±2.90) vs.(5.26 ±1.65), P <0.01],the treatment group de-creased more obvious than control group ( P <0.05);compared with before treatment, bone density were improved in treat-ment group( P <0.05), while no significant improvement were found in control group ( P >0.05).Compared with the con-trol group, the treatment group’s pain scores, lumbar spine and femoral neck BMD were improved obviously , the difference was statistically significant ( P <0.05).Conclusion Atorvastatin has a synergistic effect on Qianggu capsules in the treat-ment of elderly patients with type 2 diabetic osteoporosis therapy .